T-cell depletion: from positive selection to negative depletion in adult patients

被引：4

作者：

Aversa, F. ^{[1
]}

机构：

[1] Univ Parma, Osped Maggiore, Dept Clin & Expt Med, I-43126 Parma, Italy

来源：

BONE MARROW TRANSPLANTATION | 2015年 / 50卷

关键词：

BONE-MARROW-TRANSPLANTATION; RISK ACUTE-LEUKEMIA; DONOR LYMPHOCYTES; PROGENITOR CELLS; HAPLOTYPE; MEGADOSE; DISEASE;

D O I：

10.1038/bmt.2015.88

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Clinical trials have shown that a strategy for haploidentical transplantation based on the infusion of high numbers of T-cell-depleted hematopoietic progenitor cells and no post-transplant immunosuppression controls graft rejection and GvHD in patients with acute leukemia. Overall, event-free survival compares favorably with reports of transplants using sources of stem cells other than the matched sibling. Current studies are focussing on rebuilding post-transplant immunity to improve clinical outcomes separating GvHD from favourable donor immune responses.

引用

页码：S11 / S13

页数：3

共 23 条

[1]

[Anonymous], BLOOD, DOI DOI 10.1182/BLOOD-2010-10-311894

[2] SUCCESSFUL ENGRAFTMENT OF T-CELL-DEPLETED HAPLOIDENTICAL 3-LOCI INCOMPATIBLE TRANSPLANTS IN LEUKEMIA PATIENTS BY ADDITION OF RECOMBINANT HUMAN GRANULOCYTE-COLONY-STIMULATING FACTOR-MOBILIZED PERIPHERAL-BLOOD PROGENITOR CELLS TO BONE-MARROW INOCULUM [J].

AVERSA, F ;

TABILIO, A ;

TERENZI, A ;

VELARDI, A ;

FALZETTI, F ;

GIANNONI, C ;

IACUCCI, R ;

ZEI, T ;

MARTELLI, MP ;

GAMBELUNGHE, C ;

ROSSETTI, M ;

CAPUTO, P ;

LATINI, P ;

ARISTEI, C ;

RAYMONDI, C ;

REISNER, Y ;

MARTELLI, MF .

BLOOD, 1994, 84 (11) :3948-3955

[3] Treatment of high-risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype [J].

Aversa, F ;

Tabilio, A ;

Velardi, A ;

Cunningham, I ;

Terenzi, A ;

Falzetti, F ;

Ruggeri, L ;

Barbabietola, G ;

Aristei, C ;

Latini, P ;

Reisner, Y ;

Martelli, MF .

NEW ENGLAND JOURNAL OF MEDICINE, 1998, 339 (17) :1186-1193

[4] Full haplotype-mismatched hematopoietic stem-cell transplantation: A phase II study in patients with acute leukemia at high risk of relapse [J].

Aversa, F ;

Terenzi, A ;

Tabilio, A ;

Falzetti, F ;

Carotti, A ;

Ballanti, S ;

Felicini, R ;

Falcinelli, F ;

Velardi, A ;

Ruggeri, L ;

Aloisi, T ;

Saab, JP ;

Santucci, A ;

Perruccio, K ;

Martelli, MP ;

Mecucci, C ;

Reisner, Y ;

Martelli, MF .

JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (15) :3447-3454

[5] Haploidentical Hematopoietic Stem Cell Transplantation With a Megadose T-Cell-Depleted Graft: Harnessing Natural and Adaptive Immunity [J].

Aversa, Franco ;

Martelli, Massimo F. ;

Velardi, Andrea .

SEMINARS IN ONCOLOGY, 2012, 39 (06) :643-652

[6] MEGADOSE OF T-CELL-DEPLETED BONE-MARROW OVERCOMES MHC BARRIERS IN SUBLETHALLY IRRADIATED MICE [J].

BACHARLUSTIG, E ;

RACHAMIM, N ;

LI, HW ;

LAN, FS ;

REISNER, Y .

NATURE MEDICINE, 1995, 1 (12) :1268-1273

[7] HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia [J].

Bonini, C ;

Ferrari, G ;

Verzeletti, S ;

Servida, P ;

Zappone, E ;

Ruggieri, L ;

Ponzoni, M ;

Rossini, S ;

Mavilio, F ;

Traversari, C ;

Bordignon, C .

SCIENCE, 1997, 276 (5319) :1719-1724

[8] γδ T cells:: Functional plasticity and heterogeneity [J].

Carding, SR ;

Egan, PJ .

NATURE REVIEWS IMMUNOLOGY, 2002, 2 (05) :336-345

[9] A survey of fully haploidentical hematopoietic stem cell transplantation in adults with high-risk acute leukemia: a risk factor analysis of outcomes for patients in remission at transplantation [J].

Ciceri, Fabio ;

Labopin, Myriam ;

Aversa, Franco ;

Rowe, Jakob M. ;

Bunjes, Donald ;

Lewalle, Philippe ;

Nagler, Arnon ;

Di Bartolomeo, Paolo ;

Lacerda, Joao F. ;

Stanghellini, Maria Teresa Lupo ;

Polge, Emmanuelle ;

Frassoni, Francesco ;

Martelli, Massimo F. ;

Rocha, Vanderson .

BLOOD, 2008, 112 (09) :3574-3581

[10] Infusion of suicide-gene-engineered donor lymphocytes after family haploidentical haemopoietic stem-cell transplantation for leukaemia (the TK007 trial): a non-randomised phase I-II study [J].

Ciceri, Fabio ;

Bonini, Chiara ;

Stanghellini, Maria Teresa Lupo ;

Bondanza, Attilio ;

Traversari, Catia ;

Salomoni, Monica ;

Turchetto, Lucia ;

Colombi, Scialini ;

Bernardi, Massimo ;

Peccatori, Jacopo ;

Pescarollo, Alessandra ;

Servida, Paolo ;

Magnani, Zulma ;

Perna, Serena K. ;

Valtolina, Veronica ;

Crippa, Fulvio ;

Callegaro, Luciano ;

Spoldi, Elena ;

Crocchiolo, Roberto ;

Fleischhauer, Katharina ;

Ponzoni, Maurilio ;

Vago, Luca ;

Rossini, Silvano ;

Santoro, Armando ;

Todisco, Elisabetta ;

Apperley, Jane ;

Olavarria, Eduardo ;

Slavin, Shimon ;

Weissinger, Eva M. ;

Ganser, Arnold ;

Stadler, Michael ;

Yannaki, Evangelia ;

Fassas, Athanasios ;

Anagnostopoulos, Achilles ;

Bregni, Marco ;

Stampino, Corrado Gallo ;

Bruzzi, Paolo ;

Bordignon, Claudio .

LANCET ONCOLOGY, 2009, 10 (05) :489-500

← 1 2 3 →