Disseminated Sarcoidosis Presenting as Granulomatous Gastritis A Clinical Review of the Gastrointestinal and Hepatic Manifestations of Sarcoidosis

被引:23
作者
Dulai, Parambir S. [1 ]
Rothstein, Richard I. [1 ,2 ]
机构
[1] Dartmouth Hitchcock Med Ctr, Dept Med, Lebanon, NH 03756 USA
[2] Dartmouth Hitchcock Med Ctr, Sect Gastroenterol & Hepatol, Lebanon, NH 03756 USA
关键词
sarcoidosis; granuloma; granulomatous gastritis Helicobacter pylori; Crohn's disease; primary biliary cirrhosis; ANGIOTENSIN-CONVERTING ENZYME; PRIMARY BILIARY-CIRRHOSIS; CROHNS-DISEASE; INTESTINAL TUBERCULOSIS; DIFFERENTIAL-DIAGNOSIS; LIVER-TRANSPLANTATION; WHIPPLES-DISEASE; PATHOGENESIS; ASSOCIATION; INVOLVEMENT;
D O I
10.1097/MCG.0b013e318247106b
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Commonly considered a pulmonary disease, sarcoidosis is actually a multisystemic granulomatous disorder of unclear etiology. There is a wide range of organ system involvement, with gastrointestinal being among the rarest. We describe the diagnostic challenge of a patient presenting with gastritis without pulmonary complaints who was later found to have extrathoracic disseminated sarcoidosis. This case highlighted both the variability in the presentation of the disease and difficulties in its diagnosis. We performed a literature review to identify studies published on gastrointestinal and hepatic sarcoidosis to better understand the characteristics of this disease and help in the differentiation between other commonly encountered disorders that may be mimicked in presentation. We have also created a diagnostic approach that can be applied when endoscopic or hepatic biopsies reveal granulomas. We anticipate that this review may be useful for clinicians who face these diagnostic dilemmas and management decisions for this complex and variable condition.
引用
收藏
页码:367 / 374
页数:8
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