Kv7 (KCNQ) potassium channel activation and voltage-sensitive calcium channel inhibition as a novel mechanism of vasodilation produced by phosophodiesterase inhibitors

被引:0
|
作者
Mani, Bharath K. [1 ]
Kakad, Priyanka P. [1 ]
Byron, Kenneth L. [1 ]
机构
[1] Loyola Univ, Med Ctr, Maywood, IL 60153 USA
来源
FASEB JOURNAL | 2011年 / 25卷
关键词
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页数:1
相关论文
共 50 条
  • [41] Safety and tolerability of BHV-7000, a novel Kv7 potassium channel activator: Results from Phase 1 single and multiple ascending dose studies
    Awsare, B.
    Lerner, J.
    Ashbrenner, E.
    Sevinsky, H.
    Bozik, M.
    Dworetzky, S.
    Donahue, L.
    Killingsworth, R.
    Francoeur, B.
    Qureshi, I.
    EPILEPSIA, 2024, 65 : 158 - 158
  • [42] Safety and Tolerability of BHV-7000, a Novel Kv7 Potassium Channel Activator: Results from Phase 1 Single and Multiple Ascending Dose Studies
    Awsare, Bharat
    Lerner, Jason
    Ashbrenner, Eric
    Sevinsky, Heather
    Bozik, Michael
    Dworetzky, Steven
    Donahue, Lia
    Killingsworth, Randall
    Francoeur, Bruno
    Qureshi, Irfan
    NEUROTHERAPEUTICS, 2024, 21 (04)
  • [43] KV7 Channel Pharmacological Activation by the Novel Activator ML213: Role for Heteromeric KV7.4/KV7.5 Channels in Guinea Pig Detrusor Smooth Muscle Functions
    Provence, Aaron
    Angoli, Damiano
    Petkov, Georgi V.
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2018, 364 (01): : 131 - 144
  • [44] Use of intrathecal SNX-111, a novel, N-type, voltage-sensitive, calcium channel blocker, in the management of intractable brachial plexus avulsion pain
    Brose, WG
    Gutlove, DP
    Luther, RR
    Bowersox, SS
    McGuire, D
    CLINICAL JOURNAL OF PAIN, 1997, 13 (03): : 256 - 259
  • [45] THE VOLTAGE-SENSITIVE SODIUM CHANNEL NAV1.7 IS EXPRESSED IN HUMAN AIRWAY EPITHELIAL CELLS PROVIDING SUPPORT FOR THE MECHANISM OF ACTION OF THE NOVEL MUCOCILIARY AGENT BREVENAL
    Stevens, E.
    Vladar, E.
    Leitman, D.
    Yuan, C.
    Baden, D.
    Bourdelais, A.
    Abraham, W. M.
    Salathe, M.
    Cohen, I
    Milla, C.
    PEDIATRIC PULMONOLOGY, 2017, 52 : S326 - S326
  • [47] Chemokine (C-X-C motif) receptor 4 (CXCR4) activation in rat mesenteric artery myocytes is linked to supression of Kv7 potassium channel activity
    Byron, Kenneth L.
    Brueggemann, Lyubov I.
    LaPorte, Heather
    Majetschak, Matthias
    FASEB JOURNAL, 2019, 33
  • [48] Novel Mechanism of Voltage-Gated N-type (Cav2.2) Calcium Channel Inhibition Revealed through α-Conotoxin Vc1.1 Activation of the GABAB Receptor
    Huynh, Thuan G.
    Cuny, Hartmut
    Slesinger, Paul A.
    Adams, David J.
    MOLECULAR PHARMACOLOGY, 2015, 87 (02) : 240 - 250
  • [50] Activation of the L voltage-sensitive calcium channel by mitogen-activated protein (MAP) kinase following exposure of neuronal cells to β-amyloid -: Map kinase mediates β-amyloid-induced neurodegeneration
    Ekinci, FJ
    Malik, KU
    Shea, TB
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (42) : 30322 - 30327