Regulation of lymphocyte development and function by RNA-binding proteins

被引：14

作者：

Turner, Martin ^{[1
]}

Hodson, Daniel ^{[1
]}

机构：

[1] Babraham Inst, Lab Lymphocyte Signalling & Dev, Cambridge CB22 3AT, England

来源：

CURRENT OPINION IN IMMUNOLOGY | 2012年 / 24卷 / 02期

基金：

英国生物技术与生命科学研究理事会;

关键词：

HELPER T-CELLS; MESSENGER-RNA; GENE-EXPRESSION; ACTIVATION; STABILITY; DECAY; DEGRADATION; DYNAMICS; BRF1; PHOSPHORYLATION;

D O I：

10.1016/j.coi.2012.01.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Lymphocyte development requires cells to progress through a series of stages, each associated with changes in gene expression. Intense effort has been invested into characterising the dynamic networks of transcription factors underlying these regulated changes. Whilst transcription factors determine the tempo at which mRNA is produced, recent results highlight the importance of the selective regulation of mRNA decay and translation in regulating gene expression. These processes are regulated by sequence-specific RNA-binding proteins (RBP) as well as noncoding RNA such as microRNAs. RNA-binding proteins are emerging as important regulators of cell fate and function in both developing and mature lymphocytes. At the molecular level the function of RNA-binding proteins is integrated with signal transduction pathways that also govern gene transcription.

引用

页码：160 / 165

页数：6

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