Recent developments in the identification of novel oxazolidinone antibacterial agents

被引：125
作者：
Renslo, Adam R. [1 ]
Luehr, Gary W. [1 ]
Gordeev, Mikhail F. [1 ]
机构：
[1] Vicuron Pharmaceut, Fremont, CA 94555 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2006年 / 14卷 / 12期
关键词：
antibacterials; oxazolidinones; structure-activity relationships; protein synthesis inhibitors;
D O I：
10.1016/j.bmc.2006.01.068
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The oxazolidinones are a promising new class of synthetic antibacterial agents. Here, we review recent efforts directed at the discovery of new antibacterial compounds of this class. New structures and structure-activity relationships (SAR) are discussed in the context of earlier work in the field. Key issues of potency, spectrum, selectivity, in vivo efficacy, and pharmacokinetic profile of the new analogs are addressed. (c) 2006 Elsevier Ltd. All rights reserved.
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收藏
页码：4227 / 4240
页数：14
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