Methylation of the HOXA10 homeobox gene promoter is associated with endometrial cancer: A pilot study

被引：10

作者：

Fambrini, M. ^{[1
]}

Bussani, C. ^{[1
]}

Sorbi, F. ^{[1
]}

Pieralli, A. ^{[1
]}

Cioni, R. ^{[1
]}

机构：

[1] Univ Florence, Dept Sci Woman & Child Hlth, Florence, Italy

来源：

JOURNAL OF OBSTETRICS AND GYNAECOLOGY | 2013年 / 33卷 / 05期

关键词：

Endometrial cancer; HOXA10 homeobox gene; methylation; EXPRESSION;

D O I：

10.3109/01443615.2013.776027

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Methylation in the promoter region represents an epigenetic mechanism that silences expression of various homeobox genes in cancers. We compare the methylation profile of HOXA10 promoter gene in 19 histologically proven endometrioid cancers and 27 normal endometrial tissues. Endometrial cancer tissue displays significantly higher methylation status in HOXA10 gene promoter than normal tissue, suggesting a possible role of epigenetic changes in HOXA10 gene regulation in tumorigenesis. Further studies in human tissue and cell lines are necessary to validate these preliminary results and to investigate HOXA10 expression according to methylation status in endometrial cancer.

引用

页码：519 / 520

页数：2

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