An inflammation classification system using cytokine parameters

被引:110
作者
Roe, Kevin
机构
[1] San Jose, CA
关键词
cytokines; inflammation; inflammatory cytokines; medical diagnosis; BIOMARKERS; PATHOGENESIS; SALIVA; URINE; ALPHA;
D O I
10.1111/sji.12970
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Inflammation can be created by several different causes, including a blood clot, an immune system disorder, a cancer, an infection, a chemical exposure, a physical injury, or a neurological condition, such as Alzheimer's or depression. In particular, many infections by viral, bacterial, fungal and protozoan pathogens can cause inflammation. Inflammations can have far-reaching medical consequences, because chronic or frequent inflammation can assist cancers and initiate autoimmune diseases. Determining the cause of an inflammation can be essential for the medical treatment of an individual, and a classification system can be a useful tool to help a diagnosis, confirm a diagnosis and to determine the most appropriate treatment. However, at present there is no classification system for the different causes of inflammation. This paper describes a classification system that uses seven distinct cytokine parameters to enable the determination of the cause of an inflammation. This classification system is expandable, and it can help determine whether an inflammation is caused by an ischaemia, an immune system disorder, a cancer, an infection, a chemical, a physical injury, or a neurological condition. In some cases, this classification system can help enable a quick primary or secondary determination of an urgent medical emergency when other medical diagnostic resources are unavailable.
引用
收藏
页数:5
相关论文
共 30 条
[1]   Role of Pro-Inflammatory Cytokines and Vitamin D in Probable Alzheimer's Disease with Depression [J].
Banerjee, Anindita ;
Khemka, Vineet Kumar ;
Roy, Debashree ;
Dhar, Aparajita ;
Roy, Tapan Kumar Sinha ;
Biswas, Atanu ;
Mukhopadhyay, Barun ;
Chakrabarti, Sasanka .
AGING AND DISEASE, 2017, 8 (03) :267-276
[2]   The influence of dysfunctional signaling and lipid homeostasis in mediating the inflammatory responses during atherosclerosis [J].
Buckley, Melanie L. ;
Ramji, Dipak P. .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2015, 1852 (07) :1498-1510
[3]   Pathogenesis of malaria and clinically similar conditions [J].
Clark, IA ;
Alleva, LM ;
Mills, AC ;
Cowden, WB .
CLINICAL MICROBIOLOGY REVIEWS, 2004, 17 (03) :509-+
[4]   Impact of Cigarette Smoking on Serum Pro- and Anti-Inflammatory Cytokines and Growth Factors [J].
Daloee, Mahdi Hasanzadeh ;
Avan, Amir ;
Mirhafez, Seyed Reza ;
Kavousi, Elahe ;
Hasanian-Mehr, Mehdi ;
Darroudi, Sousan ;
Tajfard, Mohammad ;
Tayefi, Maryam ;
Qazizade, Hanie ;
Mohammadi, Akram ;
Ferydouni, Narges ;
Ebrahimi, Mahmoud ;
Ghayour-Mobarhan, Majid .
AMERICAN JOURNAL OF MENS HEALTH, 2017, 11 (04) :1169-1173
[5]   The Role of Cytokines in the Pathogenesis and Treatment of Systemic Lupus Erythematosus [J].
Davis, Laurie S. ;
Hutcheson, Jack ;
Mohan, Chandra .
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2011, 31 (10) :781-789
[6]   The Number of Elevated Cytokines and Chemokines in Preclinical Seropositive Rheumatoid Arthritis Predicts Time to Diagnosis in an Age-Dependent Manner [J].
Deane, Kevin D. ;
O'Donnell, Colin I. ;
Hueber, Wolfgang ;
Majka, Darcy S. ;
Lazar, Ann A. ;
Derber, Lezlie A. ;
Gilliland, William R. ;
Edison, Jess D. ;
Norris, Jill M. ;
Robinson, William H. ;
Holers, V. Michael .
ARTHRITIS AND RHEUMATISM, 2010, 62 (11) :3161-3172
[7]   Cytokines Association with Clinical and Pathological Changes in Esophageal Squamous Cell Carcinoma [J].
Diakowska, Dorota .
DISEASE MARKERS, 2013, 2013 :883-893
[8]  
Doll DN, 2014, AGING DIS, V5, P294, DOI 10.14336/AD.2014.0500294
[9]   The Role of Cytokines in Breast Cancer Development and Progression [J].
Esquivel-Velazquez, Marcela ;
Ostoa-Saloma, Pedro ;
Isabel Palacios-Arreola, Margarita ;
Nava-Castro, Karen E. ;
Ivonne Castro, Julieta ;
Morales-Montor, Jorge .
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2015, 35 (01) :1-16
[10]   Cytokines, IBD, and Colitis-associated Cancer [J].
Francescone, Ralph ;
Hou, Vivianty ;
Grivennikov, Sergei I. .
INFLAMMATORY BOWEL DISEASES, 2015, 21 (02) :409-418