Interleukin-27: a potential new sepsis biomarker exposed through genome-wide transcriptional profiling

被引：13

作者：

Scicluna, Brendon P. ^{[1
]}

van der Poll, Tom ^{[1
,2
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Ctr Expt & Mol Med, NL-1105 AZ Amsterdam, Netherlands

[2] Univ Amsterdam, Acad Med Ctr, Div Infect Dis, NL-1105 AZ Amsterdam, Netherlands

来源：

CRITICAL CARE | 2012年 / 16卷 / 06期

关键词：

Melioidosis; High Predictive Power; Adult Intensive Care Unit; Adult Intensive Care Unit Patient; Intensive Care Unit Cohort;

D O I：

10.1186/cc11893

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Sepsis is a complex clinical condition that is driven predominantly by deviations from the orderly stereotypic immunological response to infection. Much effort has been undertaken in the search for biomarkers that can assist in discriminating critically ill patients with sterile inflammation from those with sepsis. Such biomarkers may aid the clinician in therapeutic decision making upon admission of a patient. Interleukin-27 may be such a discriminative biomarker, as suggested in the previous issue of Critical Care by a study of critically ill children.

引用

页数：2

共 7 条

[1]

Rinchai D, 2012, EUR J IMMUNOL

[2] Development and validation of a novel molecular biomarker diagnostic test for the early detection of sepsis [J].

Sutherland, Allison ;

Thomas, Mervyn ;

Brandon, Roslyn A. ;

Brandon, Richard B. ;

Lipman, Jeffrey ;

Tang, Benjamin ;

McLean, Anthony ;

Pascoe, Ranald ;

Price, Gareth ;

Thu Nguyen ;

Stone, Glenn ;

Venter, Deon .

CRITICAL CARE, 2011, 15 (03)

[3] Genome-wide transcription profiling of human sepsis: a systematic review [J].

Tang, Benjamin M. ;

Huang, Stephen J. ;

McLean, Anthony S. .

CRITICAL CARE, 2010, 14 (06)

[4] Serum MicroRNA Signatures Identified by Solexa Sequencing Predict Sepsis Patients' Mortality: A Prospective Observational Study [J].

Wang, Huijuan ;

Zhang, Pengjun ;

Chen, Weijun ;

Feng, Dan ;

Jia, Yanhong ;

Xie, Lixin .

PLOS ONE, 2012, 7 (06)

[5] Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27 [J].

Wirtz, Stefan ;

Tubbe, Ingrid ;

Galle, Peter R. ;

Schild, Hans J. ;

Birkenbach, Mark ;

Blumberg, Richard S. ;

Neurath, Markus F. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2006, 203 (08) :1875-1881

[6] Interleukin-27 is a novel candidate diagnostic biomarker for bacterial infection in critically ill children [J].

Wong, Hector R. ;

Cvijanovich, Natalie Z. ;

Hall, Mark ;

Allen, Geoffrey L. ;

Thomas, Neal J. ;

Freishtat, Robert J. ;

Anas, Nick ;

Meyer, Keith ;

Checchia, Paul A. ;

Lin, Richard ;

Bigham, Michael T. ;

Sen, Anita ;

Nowak, Jeffrey ;

Quasney, Michael ;

Henricksen, Jared W. ;

Chopra, Arun ;

Banschbach, Sharon ;

Beckman, Eileen ;

Harmon, Kelli ;

Lahni, Patrick ;

Shanley, Thomas P. .

CRITICAL CARE, 2012, 16 (05)

[7]

Wong HR, 2012, CRIT CARE, V16, DOI [10.1186/cc10811, 10.1186/cc10537]

← 1 →