Genome-wide association study of chronic periodontitis in a general German population

被引：114

作者：

Teumer, Alexander ^{[1
]}

Holtfreter, Birte ^{[2
]}

Voelker, Uwe ^{[1
]}

Petersmann, Astrid ^{[3
]}

Nauck, Matthias ^{[3
]}

Biffar, Reiner ^{[4
]}

Voelzke, Henry ^{[5
]}

Kroemer, Heyo K. ^{[6
]}

Meisel, Peter ^{[2
]}

Homuth, Georg ^{[1
]}

Kocher, Thomas ^{[2
]}

机构：

[1] Ernst Moritz Arndt Univ Greifswald, Univ Med Greifswald, Dept Funct Genom, Interfac Inst Genet & Funct Genom, D-17475 Greifswald, Germany

[2] Ernst Moritz Arndt Univ Greifswald, Univ Med Greifswald, Dept Restorat Dent Periodontol & Endodontol, Unit Periodontol, D-17475 Greifswald, Germany

[3] Ernst Moritz Arndt Univ Greifswald, Univ Med Greifswald, Inst Clin Chem & Lab Med, D-17475 Greifswald, Germany

[4] Ernst Moritz Arndt Univ Greifswald, Univ Med Greifswald, Dept Prosthet Dent Gerostomatol & Dent Mat, D-17475 Greifswald, Germany

[5] Ernst Moritz Arndt Univ Greifswald, Univ Med Greifswald, Inst Community Med, D-17475 Greifswald, Germany

[6] Ernst Moritz Arndt Univ Greifswald, Univ Med Greifswald, CDAT, Dept Pharmacol, D-17475 Greifswald, Germany

来源：

JOURNAL OF CLINICAL PERIODONTOLOGY | 2013年 / 40卷 / 11期

关键词：

attachment loss; genome-wide association studies; periodontitis; Study of Health in Pomerania; POMERANIA SHIP; CASE DEFINITIONS; GENETIC-BASIS; DISEASE; HEALTH; RISK; LOCI; VARIANTS; SUSCEPTIBILITY; SURVEILLANCE;

D O I：

10.1111/jcpe.12154

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

AimTo identify loci associated with chronic periodontitis through a genome-wide association study (GWAS). Materials and MethodsA GWAS was performed in 4032 individuals of two independent cross-sectional studies of West Pomerania (SHIP n=3365 and SHIP-TREND n=667) with different periodontal case definitions. Samples were genotyped with the Affymetrix Genome-Wide Human SNP Array 6.0 or the Illumina Human Omni 2.5 array. Imputation of the HapMap as well as the 1000 Genome-based autosomal and X-chromosomal genotypes and short insertions and deletions (INDELs) was performed in both cohorts. Finally, more than 17 million SNPs and short INDELs were analysed. ResultsNo genome-wide significant associations were found for any periodontitis case definition, regardless of whether individuals aged >60years where excluded or not. Despite no single SNP association reached genome-wide significance, the proportion of variance explained by additive effects of all common SNPs was around 23% for mean proximal attachment loss. Excluding subjects aged >60years increased the explained variance to 34%. ConclusionsNo single SNPs were found to be genome-wide significantly associated with chronic periodontitis in this study.

引用

页码：977 / 985

页数：9

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