Inflammation and Oxidative Stress in Diabetic Nephropathy: New Insights on Its Inhibition as New Therapeutic Targets

被引：170

作者：

Mima, Akira ^{[1
]}

机构：

[1] Univ Tokushima, Inst Hlth Biosci, Grad Sch Med, Dept Nephrol, Tokushima 7708503, Japan

来源：

JOURNAL OF DIABETES RESEARCH | 2013年 / 2013卷

基金：

日本学术振兴会;

关键词：

PROTEIN-KINASE-C; MONOCYTE CHEMOATTRACTANT PROTEIN-1; PROLIFERATOR-ACTIVATED RECEPTORS; VITAMIN-E SUPPLEMENTATION; FACTOR-KAPPA-B; RENAL INJURY; ENDOTHELIAL-CELLS; MACROPHAGE RECRUITMENT; CARDIOVASCULAR EVENTS; REDUCES PROTEINURIA;

D O I：

10.1155/2013/248563

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diabetes and insulin resistance can greatly increase microvascular complications of diabetes including diabetic nephropathy (DN). Hyperglycemic control in diabetes is key to preventing the development and progression of DN. However, it is clinically very difficult to achieve normal glucose control in individual diabetic patients. Many factors are known to contribute to the development of DN. These include diet, age, lifestyle, or obesity. Further, inflammatory-or oxidative-stress-induced basis for DN has been gaining interest. Although anti-inflammatory or antioxidant drugs can show benefits in rodent models of DN, negative evidence from large clinical studies indicates that more effective anti-inflammatory and antioxidant drugs need to be studied to clear this question. In addition, our recent report showed that potential endogenous protective factors could decrease inflammation and oxidative stress, showing great promise for the treatment of DN.

引用

页数：8

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