Black Soybean Seed Coat Extract Ameliorates Hyperglycemia and Insulin Sensitivity via the Activation of AMP-Activated Protein Kinase in Diabetic Mice

被引：122

作者：

Kurimoto, Yuta ^{[1
]}

Shibayama, Yuki ^{[1
]}

Inoue, Seiya ^{[1
]}

Soga, Minoru ^{[1
]}

Takikawa, Masahito ^{[1
]}

Ito, Chiaki ^{[2
]}

Nanba, Fumio ^{[2
]}

Yoshida, Tadashi

Yamashita, Yoko ^{[3
]}

Ashida, Hitoshi ^{[3
]}

Tsuda, Takanori ^{[1
]}

机构：

[1] Chubu Univ, Coll Biosci & Biotechnol, Kasugai, Aichi 4878501, Japan

[2] Fujicco Co Ltd, Dept Res & Dev, Chuo Ku, Kobe, Hyogo 6508558, Japan

[3] Kobe Univ, Grad Sch Agr Sci, Kobe, Hyogo 6578501, Japan

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2013年 / 61卷 / 23期

关键词：

black soybean; diabetes; anthocyanin; procyanidins; PROCYANIDIN DIMERS; ANTHOCYANINS; LIVER; BIOAVAILABILITY; GENISTEIN; OBESITY; HEALTH; ADIPOCYTES; PROGRESS; CASCADE;

D O I：

10.1021/jf401190y

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Black soybean seed coat has abundant levels of polyphenols such as anthocyanins (cyanidin 3-glucoside; C3G) and procyanidins (PCs). This study found that dietary black soybean seed coat extract (BE) ameliorates hyperglycemia and insulin sensitivity via the activation of AMP-activated protein kinase. (AMPK) in type 2 diabetic mice. Dietary BE significantly reduced blood glucose levels and enhanced insulin sensitivity. AMPK was activated in the skeletal muscle and liver of diabetic mice fed BE. This activation was accompanied by the up-regulation of glucose transporter 4 in skeletal muscle and the down-regulation of gluconeogenesis in the liver. These changes resulted in improved hyperglycemia and insulin sensitivity in type 2 diabetic mice. In vitro studies using L6 myotubes showed that C3G and PCs significantly induced AMPK activation and enhanced glucose uptake into the cells.

引用

页码：5558 / 5564

页数：7

共 40 条

[1] Liver adenosine monophosphate-activated kinase-α2 catalytic subunit is a key target for the control of hepatic glucose production by adiponectin and leptin but not insulin [J].

Andreelli, F ;

Foretz, M ;

Knauf, C ;

Cani, PD ;

Perrin, C ;

Iglesias, MA ;

Pillot, B ;

Bado, A ;

Tronche, F ;

Mithieux, G ;

Vaulont, S ;

Burcelin, R ;

Viollet, B .

ENDOCRINOLOGY, 2006, 147 (05) :2432-2441

[2] Procyanidin Dimers A1, A2, and B2 Are Absorbed without Conjugation or Methylation from the Small Intestine of Rats [J].

Appeldoorn, Maaike M. ;

Vincken, Jean-Paul ;

Gruppen, Harry ;

Hollman, Peter C. H. .

JOURNAL OF NUTRITION, 2009, 139 (08) :1469-1473

[3]

Brondani LD, 2012, ARQ BRAS ENDOCRINOL, V56, P215, DOI 10.1590/S0004-27302012000400001

[4] Dietary phytoestrogens activate AMP-activated protein kinase with improvement in lipid and glucose metabolism [J].

Cederroth, Christopher R. ;

Vinciguerra, Manlio ;

Gjinovci, Asllan ;

Kuehne, Francoise ;

Klein, Marcella ;

Cederroth, Manon ;

Caille, Dorothee ;

Suter, Mariane ;

Neumann, Dietbert ;

James, Richard W. ;

Doerge, Daniel R. ;

Wallimann, Theo ;

Meda, Paolo ;

Foti, Michelangelo ;

Rohner-Jeanrenaud, Francoise ;

Vassalli, Jean-Dominique ;

Nef, Serge .

DIABETES, 2008, 57 (05) :1176-1185

[5] Daidzein and the daidzein metabolite, equol, enhance adipocyte differentiation and PPARγ transcriptional activity [J].

Cho, Kae Won ;

Lee, Ok-Hwan ;

Banz, William J. ;

Moustaid-Moussa, Naima ;

Shay, Neil F. ;

Kim, Young-Cheul .

JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2010, 21 (09) :841-847

[6] Isolation and determination of anthocyanins in seed coats of black soybean (Glycine max (L.) merr.) [J].

Choung, MG ;

Baek, IY ;

Kang, ST ;

Han, WY ;

Shin, DC ;

Moon, HP ;

Kang, KH .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2001, 49 (12) :5848-5851

[7] Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, suppresses hepatic gluconeogenesis through 5′-AMP-activated protein kinase [J].

Collins, Qu Fan ;

Liu, Hui-Yu ;

Pi, Jingbo ;

Liu, Zhenqi ;

Quon, Michael J. ;

Cao, Wenhong .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (41) :30143-30149

[8] Flavanols and Anthocyanins in Cardiovascular Health: A Review of Current Evidence [J].

de Pascual-Teresa, Sonia ;

Moreno, Diego A. ;

Garcia-Viguera, Cristina .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2010, 11 (04) :1679-1703

[9] Obesity wars: Molecular progress confronts an expanding epidemic [J].

Flier, JS .

CELL, 2004, 116 (02) :337-350

[10] Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver [J].

Foretz, M ;

Ancellin, N ;

Amdreelli, F ;

Saintillan, Y ;

Grondin, P ;

Kahn, A ;

Thorens, B ;

Vaulont, S ;

Viollet, B .

DIABETES, 2005, 54 (05) :1331-1339

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