A Convenient Synthesis of Novel Functionalized Pyrimido[5′,4′:4,5]thieno[3,2-c]pyridazines and Related Fused Systems

被引：3
作者：
Aly, A. A. [1 ]
机构：
[1] Benha Univ, Fac Sci, Dept Chem, Banha, Egypt
来源：
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2008年 / 183卷 / 12期
关键词：
Antimicrobial activities; pyrimidothienopyridazines; pyridazinothienotriazines; pyridothienopyridazines; thieno[3; 2-c]pyridazine;
D O I：
10.1080/10426500802060040
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Possible approaches to the synthesis of functionalized, pyrimido[5',4':4,5]thieno [3,2-c]pyridazines 2-18, pyridazino[3',4':4,5]thieno[2,3-d]triazines 19, 20a,b and pyrido[3',2':4,5]thieno[3,2-c]pyridazines 22a,b are described. The sequence involves the heterocyclization of 6-amino-1,3-diphenyl-1,4-dihydrothieno[3,2-c]pyridazine-7-carboxamide (1) with appropriate reagents. The antimicrobial activity of some the newly synthesized compounds was examined. All tested compounds proved to be active as antibacterial and antifungal agents.
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收藏
页码：3079 / 3096
页数：18
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