Altered fovea in AQP4-IgG-seropositive neuromyelitis optica spectrum disorders

被引：45

作者：

Motamedi, Seyedamirhosein ^{[1
,2
]}

Oertel, Frederike C. ^{[1
,2
,3
]}

Yadav, Sunil K. ^{[2
,4
]}

Kadas, Ella M. ^{[2
,4
]}

Weise, Margit ^{[5
]}

Havla, Joachim ^{[6
]}

Ringelstein, Marius ^{[5
,7
]}

Aktas, Orhan ^{[5
]}

Albrecht, Philipp ^{[5
]}

Ruprecht, Klemens ^{[8
]}

Bellmann-Strobl, Judith ^{[1
,2
]}

Zimmermann, Hanna G. ^{[1
,2
]}

Paul, Friedemann ^{[1
,2
,8
]}

Brandt, Alexander U. ^{[1
,2
,9
]}

机构：

[1] Max Delbruck Ctr Mol Med, Expt & Clin Res Ctr, Berlin, Germany

[2] Charite Univ Med Berlin, NeuroCure Clin Res Ctr, Berlin, Germany

[3] Univ Calif San Francisco, Div Neuroinflammat & Glial Biol, San Francisco, CA 94143 USA

[4] Nocturne GmbH, Berlin, Germany

[5] Heinrich Heine Univ, Fac Med, Dept Neurol, Dusseldorf, Germany

[6] Ludwig Maximilians Univ Munchen, LMU Hosp, Inst Clin Neuroimmunol, Munich, Germany

[7] LVR Klinikum Dusseldorf, Ctr Neurol & Neuropsychiat, Dept Neurol, Dusseldorf, Germany

[8] Charite Univ Med Berlin, Dept Neurol, Berlin, Germany

[9] Univ Calif Irvine, Dept Neurol, Irvine, CA 92717 USA

来源：

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION | 2020年 / 7卷 / 05期

关键词：

COHERENCE TOMOGRAPHY; RETINAL PATHOLOGY; AQUAPORIN-4; FEATURES; LAYER;

D O I：

10.1212/NXI.0000000000000805

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective To investigate disease-specific foveal shape changes in patients with neuromyelitis optica spectrum disorders (NMOSDs) using foveal morphometry. Methods This cross-sectional study included macular spectral domain optical coherence tomography scans of 52 eyes from 28 patients with aquaporin-4 immunoglobulin G (AQP4-IgG)-seropositive NMOSD, 116 eyes from 60 patients with MS, and 123 eyes from 62 healthy controls (HCs), retrospectively, and an independent confirmatory cohort comprised 33/33 patients with NMOSD/MS. The fovea was characterized using 3D foveal morphometry. We included peripapillary retinal nerve fiber layer (pRNFL) thickness and combined macular ganglion cell and inner plexiform layer (GCIPL) volume to account for optic neuritis (ON)-related neuroaxonal damage. Results Group comparison showed significant differences compared with HC in the majority of foveal shape parameters in NMOSD, but not MS. Pit flat disk area, average pit flat disk diameter, inner rim volume, and major slope disk length, as selected parameters, showed differences between NMOSD and MS (p value = 0.017, 0.002, 0.005, and 0.033, respectively). This effect was independent of ON. Area under the curve was between 0.7 and 0.8 (receiver operating characteristic curve) for discriminating between NMOSD and MS. Pit flat disk area and average pit flat disk diameter changes independent of ON were confirmed in an independent cohort. Conclusions Foveal morphometry reveals a wider and flatter fovea in NMOSD in comparison to MS and HC. Comparison to MS and accounting for ON suggest this effect to be at least in part independent of ON. This supports a primary retinopathy in AQP4-IgG-seropositive NMOSD.

引用

页数：11