Insights into the role of adipose-derived stem cells: Wound healing and clinical regenerative potential

被引:17
作者
Zou, Ming-Li [1 ,2 ]
Liu, Si-Yu [1 ,2 ]
Sun, Zi-Li [1 ,2 ]
Wu, Jun-Jie [2 ]
Yuan, Zheng-Dong [2 ]
Teng, Ying-Ying [2 ]
Feng, Yi [2 ,3 ]
Yuan, Feng-Lai [1 ,2 ,4 ]
机构
[1] Nanjing Univ Chinese Med, Sch Integrated Chinese & Western Med, Wuxi Clin Med, Wuxi, Jiangsu, Peoples R China
[2] Jiangnan Univ, Dept Burns & Plast Surg, Affiliated Hosp, Wuxi 214041, Jiangsu, Peoples R China
[3] Yangzhou Univ, Med Sch, Dept Pharmacol, Yangzhou, Jiangsu, Peoples R China
[4] Nantong Univ, Dept Cent Lab, Hosp 3, Wuxi, Jiangsu, Peoples R China
关键词
adipose-derived stem cells; fat grafting; regenerative; tissue repair; wound healing; TISSUE; DIFFERENTIATION; ANGIOGENESIS; EXPRESSION; EXOSOMES; THERAPY;
D O I
10.1002/jcp.30019
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The incidence of acute and chronic wound diseases is rising due to various reasons. With complicated pathogenesis, long course, difficult treatment and high disability, wound diseases have become a major burden for patients, their families, and society. Therefore, the focus of research is to identify new ideas and methods for treatment. Fat grafting has gained increased attention because of its effectiveness in wound treatment, and further analysis has uncovered that the stem cells derived from fat may be the main factor affecting wound healing. We summarize the function of adipose stem cells and analyze their possible mechanisms in tissue repair, helping to provide new ideas for the treatment of wound healing.
引用
收藏
页码:2290 / 2297
页数:8
相关论文
共 46 条
[1]   Pressure distribution and flow characteristics during negative pressure wound therapy [J].
Biermann, Niklas ;
Geissler, Edward K. ;
Brix, Eva ;
Schiltz, Daniel ;
Muehle, Clemens ;
Prantl, Lukas ;
Taeger, Christian D. .
JOURNAL OF TISSUE VIABILITY, 2020, 29 (01) :32-36
[2]   Stromal cells from the adipose tissue-derived stromal vascular fraction and culture expanded adipose tissue-derived stromal/stem cells: a joint statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT) [J].
Bourin, Philippe ;
Bunnell, Bruce A. ;
Casteilla, Louis ;
Dominici, Massimo ;
Katz, Adam J. ;
March, Keith L. ;
Redl, Heinz ;
Rubin, J. Peter ;
Yoshimura, Kotaro ;
Gimble, Jeffrey M. .
CYTOTHERAPY, 2013, 15 (06) :641-648
[3]   Can chondral healing be improved following microfracture? The effect of adipocyte tissue derived stem cell therapy [J].
Ceylan, Hasan H. ;
Bilsel, Kerem ;
Buyukpinarbasili, Nur ;
Ceylan, Hamid ;
Erdil, Mehmet ;
Tuncay, Ibrahim ;
Sen, Cengiz .
KNEE, 2016, 23 (03) :442-449
[4]   Adipose tissue-derived stem cells inhibit hypertrophic scar (HS) fibrosis via p38/MAPK pathway [J].
Chai, Chi-Yung ;
Song, Junlong ;
Tan, Zhenwei ;
Tai, I-Chun ;
Zhang, Chaoying ;
Sun, Shengrong .
JOURNAL OF CELLULAR BIOCHEMISTRY, 2019, 120 (03) :4057-4064
[5]  
Charaghvandi DA, 2020, UNDERSEA HYPERBAR M, V47, P111, DOI 10.22462/01.03.2020.12
[6]   Efficient and sustained IGF-1 expression in the adipose tissue-derived stem cells mediated via a lentiviral vector [J].
Chen, Ting ;
Huang, Dangsheng ;
Chen, Guanghui ;
Yang, Tingshu ;
Yi, Jun ;
Tian, Miao .
JOURNAL OF MOLECULAR HISTOLOGY, 2015, 46 (01) :1-11
[7]   Exosomes from differentiating human skeletal muscle cells trigger myogenesis of stem cells and provide biochemical cues for skeletal muscle regeneration [J].
Choi, Ji Suk ;
Yoon, Hwa In ;
Lee, Kyoung Soo ;
Choi, Young Chan ;
Yang, Seong Hyun ;
Kim, In-San ;
Cho, Yong Woo .
JOURNAL OF CONTROLLED RELEASE, 2016, 222 :107-115
[8]   Facial Fat Grafting The Past, Present, and Future [J].
Egro, Francesco M. ;
Coleman, Sydney R. .
CLINICS IN PLASTIC SURGERY, 2020, 47 (01) :1-+
[9]   Nanovesicles from adipose-derived mesenchymal stem cells inhibit T lymphocyte trafficking and ameliorate chronic experimental autoimmune encephalomyelitis [J].
Farinazzo, Alessia ;
Angiari, Stefano ;
Turano, Ermanna ;
Bistaffa, Edoardo ;
Dusi, Silvia ;
Ruggieri, Serena ;
Bonafede, Roberta ;
Mariotti, Raffaella ;
Constantin, Gabriela ;
Bonetti, Bruno .
SCIENTIFIC REPORTS, 2018, 8
[10]   Targeted apoptosis of myofibroblasts by elesclomol inhibits hypertrophic scar formation [J].
Feng, Yi ;
Wu, Jun-Jie ;
Sun, Zi-Li ;
Liu, Si-Yu ;
Zou, Ming-Li ;
Yuan, Zheng-Dong ;
Yu, Shun ;
Lv, Guo-Zhong ;
Yuan, Feng-Lai .
EBIOMEDICINE, 2020, 54