Organocatalytic Enantioselective Direct Vinylogous Michael Addition of -Substituted Butenolides to 3-Aroyl Acrylates and 1,2-Diaroylethylenes

被引：52

作者：

Das, Utpal ^{[1
]}

Chen, Yi-Ru ^{[1
]}

Tsai, Yi-Ling ^{[1
]}

Lin, Wenwei ^{[1
]}

机构：

[1] Natl Taiwan Normal Univ, Dept Chem, Taipei 11677, Taiwan

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2013年 / 19卷 / 24期

关键词：

cinchona alkaloids; -butenolides; Michael addition; organocatalysis; quaternary stereogenic center; MUKAIYAMA ALDOL REACTIONS; CARBON QUATERNARY STEREOCENTERS; CHIRAL GUANIDINE BASE; CONJUGATE ADDITIONS; GAMMA-BUTENOLIDE; NATURAL-PRODUCTS; ASYMMETRIC-SYNTHESIS; CINCHONA ALKALOIDS; CONSTRUCTION; CATALYSIS;

D O I：

10.1002/chem.201301332

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Adding value: The direct vinylogous Michael addition of γ-substituted butenolides with a series of 3-aroyl acrylates and 1,2-diaroylethylenes has been demonstrated. This organocatalytic method delivers highly enantio- and diastereomerically pure γ,γ-disubstituted butenolides with adjacent quaternary and tertiary stereocenters (see scheme). Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：7713 / 7717

页数：5

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