Toward a New Molecular Taxonomy of Diffuse Large B-cell Lymphoma

被引：63

作者：

Ennishi, Daisuke ^{[1
]}

Hsi, Eric D. ^{[2
]}

Steidl, Christian ^{[1
]}

Scott, David W. ^{[1
]}

机构：

[1] British Columbia Canc Ctr Lymphoid Canc, Vancouver, BC, Canada

[2] Cleveland Clin, Dept Lab Med, Cleveland, OH 44106 USA

来源：

CANCER DISCOVERY | 2020年 / 10卷 / 09期

关键词：

RITUXIMAB PLUS CYCLOPHOSPHAMIDE; GERMINAL CENTER FORMATION; CLASS-II EXPRESSION; GENE-EXPRESSION; SOMATIC MUTATIONS; FOLLICULAR LYMPHOMA; CODING GENOME; MYC STATUS; R-CHOP; BCL2;

D O I：

10.1158/2159-8290.CD-20-0174

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Diffuse large B-cell lymphoma (DLBCL) represents a grouping of clinically and biologically heterogeneous tumors. Application of advanced molecular technology has significantly expanded our knowledge of DLBCL pathobiology, allowing identification of subgroups with common, potentially targetable, biological themes. Here, we review the recent molecular analyses that could provide a paradigm shift to a new taxonomy, foundational to the rational transition to precision medicine. We discuss how classification systems may be synthesized into a common taxonomy, drawing strength from the relationships between genetic alterations, gene expression, and tumor microenvironment. Finally, challenges to translating such a taxonomy to the clinic will be outlined.

引用

页码：1267 / 1281

页数：15

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