Chemical genetics: exploring and controlling cellular processes with chemical probes

被引：107

作者：

Crews, CM ^{[1
]}

Splittgerber, U

机构：

[1] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA

[2] Yale Univ, Dept Pharmacol, New Haven, CT 06520 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1999年 / 24卷 / 08期

关键词：

D O I：

10.1016/S0968-0004(99)01425-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The new field of chemical biology brings together chemists and biologists who are seeking to understand and mimic the natural world. One research strategy in this new field is the development of biologically active small molecules as molecular probes. This approach, which has been called 'chemical' genetics, has allowed elucidation of several pathways that have been difficult to study using traditional genetic approaches.

引用

页码：317 / 320

页数：4

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