HIV-1 envelope glycoprotein structure

被引：69

作者：

Merk, Alan ^{[1
]}

Subramaniam, Sriram ^{[1
]}

机构：

[1] NCI, Cell Biol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2013年 / 23卷 / 02期

关键词：

VIRUS TYPE-1 GP41; INTERHELICAL INTERACTIONS; CRYOELECTRON TOMOGRAPHY; POTENT NEUTRALIZATION; FUNCTIONAL-ANALYSIS; ATOMIC-STRUCTURE; ANTIBODY; GP120; CORE; MEMBRANE;

D O I：

10.1016/j.sbi.2013.03.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The trimeric envelope glycoprotein of HIV-1, composed of gp120 and gp41 subunits, remains a major target for vaccine development. The structures of the core regions of monomeric gp120 and gp41 have been determined previously by X-ray crystallography. New insights into the structure of trimeric HIV-1 envelope glycoproteins are now coming from cryo-electron tomographic studies of the gp120/gp41 trimer as displayed on intact viruses and from cryo-electron microscopic studies of purified, soluble versions of the ectodomain of the trimer. Here, we review recent developments in these fields as they relate to our understanding of the structure and function of HIV-1 envelope glycoproteins.

引用

页码：268 / 276

页数：9

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