The Use of Mesenchymal (Skeletal) Stem Cells for Treatment of Degenerative Diseases: Current Status and Future Perspectives

被引：74
作者：
Abdallah, Basem M. [1 ]
Kassem, Moustapha
机构：
[1] Univ So Denmark, Odense Univ Hosp, Mol Endocrinol Lab KMEB, Dept Endocrinol,Med Biotechnol Ctr, DK-5000 Odense C, Denmark
来源：
JOURNAL OF CELLULAR PHYSIOLOGY | 2009年 / 218卷 / 01期
基金：
英国医学研究理事会;
关键词：
HUMAN BONE-MARROW; STROMAL CELLS; IN-VITRO; MONOLAYER-CULTURES; CARDIAC-FUNCTION; ADIPOSE-TISSUE; LIFE-SPAN; TRANSPLANTATION; REPAIR; OSTEOGENESIS;
D O I：
10.1002/jcp.21572
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Human bone marrow derived-mesenchymal (skeletal) stem (MSC) cells are a group of non-hematopoietic stem cells residing in the perivascular niches in bone marrow. These cells have the capacity to differentiate mainly into mesoderm-type cells such as osteoblasts, chondrocytes and adipocytes and possibly but not proven to non-mesodermal cell types. Recently, there has been an increased interest in understanding the biology of MSC due to their potential use in cell-based therapy for multiple degenerative diseases. Here, we will provide an update on the current status of these novel therapeutic opportunities.
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页码：9 / 12
页数：4
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