Campylobacter sugars sticking out

被引：107

作者：

Guerry, Patricia ^{[1
]}

Szymanski, Christine M. ^{[2
]}

机构：

[1] USN, Med Res Ctr, Enter Dis Dept, Silver Spring, MD 20910 USA

[2] CNR, Inst Biol Sci, Ottawa, ON K1A 0R6, Canada

来源：

TRENDS IN MICROBIOLOGY | 2008年 / 16卷 / 09期

关键词：

D O I：

10.1016/j.tim.2008.07.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The amazing repertoire of glycoconjugates that are found in Campylobacter jejuni includes lipooligosaccharides mimicking human glycolipids, capsular polysaccharides with complex and unusual sugars, and proteins that are post-translationally modified with either O- or Winked glycans. Thus, the glycome of this important food-borne pathogen is an excellent toolbox for glycobiologists to understand the fundamentals of these pathways and their role in host-microbe interactions, develop new techniques for glycobiology and exploit these pathways for novel diagnostics and therapeutics. The exciting surge in recent research activities will be summarized in this review.

引用

页码：428 / 435

页数：8

共 75 条

[1] Two distinct but interchangeable mechanisms for flipping of lipid-linked oligosaccharides [J].

Alaimo, C ;

Catrein, I ;

Morf, L ;

Marolda, CL ;

Callewaert, N ;

Valvano, MA ;

Feldman, MF ;

Aebi, M .

EMBO JOURNAL, 2006, 25 (05) :967-976

[2]

Allos BM, 2001, CLIN INFECT DIS, V32, P1201, DOI 10.1086/319760

[3] Structure of Campylobacter jejuni lipopolysaccharides determines antiganglioside specificity and clinical features of Guillain-Barre, and Miller Fisher patients [J].

Ang, CW ;

Laman, JD ;

Willison, HJ ;

Wagner, ER ;

Endtz, HP ;

De Klerk, MA ;

Tio-Gillen, AP ;

Van den Braak, N ;

Jacobs, BC ;

Van Doorn, PA .

INFECTION AND IMMUNITY, 2002, 70 (03) :1202-1208

[4] CHEMICAL STRUCTURES OF THE CORE REGION OF CAMPYLOBACTER-JEJUNI O/3 LIPOPOLYSACCHARIDE AND AN ASSOCIATED POLYSACCHARIDE [J].

ASPINALL, GO ;

LYNCH, CM ;

PANG, H ;

SHAVER, RT ;

MORAN, AP .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1995, 231 (03) :570-578

[5] A phase-variable capsule is involved in virulence of Campylobacter jejuni 81-176 [J].

Bacon, DJ ;

Szymanski, CM ;

Burr, DH ;

Silver, RP ;

Alm, RA ;

Guerry, P .

MOLECULAR MICROBIOLOGY, 2001, 40 (03) :769-777

[6] Single bifunctional UDP-GlcNAc/Glc 4-epimerase supports the synthesis of three cell surface glycoconjugates in Campylobacter jejuni [J].

Bernatchez, S ;

Szymanski, CM ;

Ishiyama, N ;

Li, JJ ;

Jarrell, HC ;

Lau, PC ;

Berghuis, AM ;

Young, NM ;

Wakarchuk, WW .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (06) :4792-4802

[7] Tolerance to self gangliosides is the major factor restricting the antibody response to lipopolysaccharide core oligosaccharides in Campylobacter jejuni strains associated with Guillain-Barre syndrome [J].

Bowes, T ;

Wagner, ER ;

Boffey, J ;

Nicholl, D ;

Cochrane, L ;

Benboubetra, M ;

Conner, J ;

Furukawa, K ;

Willison, HJ .

INFECTION AND IMMUNITY, 2002, 70 (09) :5008-5018

[8] Polyisoprenol specificity in the Campylobacter jejuni N-linked glycosylation pathway [J].

Chen, Mark M. ;

Weerapana, Eranthie ;

Ciepichal, Ewa ;

Stupak, Jacek ;

Reid, Christopher W. ;

Swiezewska, Ewa ;

Imperiali, Barbara .

BIOCHEMISTRY, 2007, 46 (50) :14342-14348

[9] From peptide to protein:: Comparative analysis of the substrate specificity of N-linked glycosylation in C-jejuni [J].

Chen, Mark M. ;

Glover, Kerney Jebrell ;

Imperiali, Barbara .

BIOCHEMISTRY, 2007, 46 (18) :5579-5585

[10] The chemical structure and genetic locus of Campylobacter jejuni CG8486 (serotype HS:4) capsular polysaccharide:: the identification of 6-deoxy-D-ido-heptopyranose [J].

Chen, Yu-Han ;

Poly, Frederic ;

Pakulski, Zbigniew ;

Guerry, Patricia ;

Monteiro, Mario A. .

CARBOHYDRATE RESEARCH, 2008, 343 (06) :1034-1040

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