Endotoxin regulates corticotropin-releasing hormone receptor 2 in heart and skeletal muscle

被引：33

作者：

Heldwein, KA ^{[1
]}

Duncan, JE ^{[1
]}

Stenzel, P ^{[1
]}

Rittenberg, MB ^{[1
]}

StenzelPoore, MP ^{[1
]}

机构：

[1] OREGON HLTH SCI UNIV,DEPT MOL MICROBIOL & IMMUNOL,PORTLAND,OR 97201

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 1997年 / 131卷 / 02期

关键词：

corticotropin-releasing hormone; heart; skeletal muscle; endotoxin; receptor; regulation;

D O I：

10.1016/S0303-7207(97)00103-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We tested the effect of endotoxin on the peripheral corticotropin-releasing hormone receptor (CRH-R2), which is highly expressed in the heart. Systemic injection of LPS markedly downregulated CRH-R2 mRNA levels in the heart in a dose and time dependent manner. In contrast, CRH-R2 levels in skeletal muscle increased following exposure to endotoxin. These results suggest that CRH-R2 may be differentially regulated in cardiac tissue and skeletal muscle. Finding that CRH-R2 expression in the heart is modulated by endotoxin, a potent inducer of cardiovascular dysregulation, suggests a possible link between CRH and the cardiovascular response to stress. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：167 / 172

页数：6

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