An Organobase (TBD)-Anchored Mesoporous Silica Nanoparticle-Catalyzed Green Synthesis of Dihydropyrano [2,3-c]pyrazoles

被引：10

作者：

Karmakar, Bikash ^{[1
]}

机构：

[1] Gobardanga Hindu Coll, Dept Chem, North 24, Khantura 743273, Parganas, India

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 2016年 / 69卷 / 10期

关键词：

HETEROGENEOUS BASIC CATALYST; ONE-POT; MULTICOMPONENT SYNTHESIS; 4-COMPONENT REACTION; NANOCRYSTALLINE MGO; EFFICIENT SYNTHESIS; DRUG DISCOVERY; PYRANOPYRAZOLES; WATER; DERIVATIVES;

D O I：

10.1071/CH15812

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient, mild, and environmental friendly method has been developed for the synthesis of dihydropyrano[2,3-c]pyrazole in ethanolic water over 1,5,7-triazabicyclo-[4,4,0]-dec-1-ene (TBD)-anchored mesoporous silica nanoparticle catalyst. The method involves the assembly of ethyl acetoacetate, hydrazine hydrate, different aldehydes, and malononitrile. It affords the corresponding product in high yield with short reaction times, while employing a very low loading of catalyst. The catalyst was reused several times without significant loss in activity.

引用

页码：1117 / 1123

页数：7

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