Trigoflavidols A-C, Degraded Diterpenoids with Antimicrobial Activity, from Trigonostemon flavidus

被引：47
作者：
Tang, Gui-Hua [1 ,2 ]
Zhang, Yu [1 ]
Gu, Yu-Cheng [3 ]
Li, Shi-Fei [1 ,2 ]
Di, Ying-Tong [1 ]
Wang, Yue-Hu [4 ]
Yang, Cui-Xian [5 ]
Zuo, Guo-Ying [5 ]
Li, Shun-Lin [1 ]
He, Hong-Ping [1 ]
Hao, Xiao-Jiang [1 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China
[2] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
[3] Syngenta, Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England
[4] Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Kunming 650201, Peoples R China
[5] Chengdu Mil Command, Kunming Gen Hosp, Sch Clin, Res Ctr Nat Med, Kunming 650032, Peoples R China
来源：
JOURNAL OF NATURAL PRODUCTS | 2012年 / 75卷 / 05期
基金：
中国国家自然科学基金;
关键词：
DAPHNANE; CONSTITUENTS; PLANT;
D O I：
10.1021/np3001128
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Trigoflavidols A (1) and B (2), tetranorditerpenoid dimers possessing a rearrangement skeleton with a spiroketal core moiety, and trigoflavidol C (3), a hexanorditerpenoid, have been isolated from Trigonostemon flavidus along with two known compounds. Compounds 1 and 2 showed moderate antimicrobial activities (MIC values: 3.12-6.25 mu g/mL) against Staphylococcus aureus, 8#MRSA, and 82#MRSA, and 1, 2, and 5 showed weak activities (IC50 values: 3.75-28.99 mu M) against various human tumor cell lines.
引用
收藏
页码：996 / 1000
页数：5
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