Metal-Free Radical-Mediated C(sp3)-H Heteroarylation of Alkanes

被引：59

作者：

Shao, Xin ^{[1
]}

Wu, Xinxin ^{[1
]}

Wu, Shuo ^{[1
]}

Zhu, Chen ^{[1
,2
]}

机构：

[1] Soochow Univ, Key Lab Organ Synth Jiangsu Prov, Coll Chem Chem Engn & Mat Sci, Suzhou 215123, Jiangsu, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Synth Chem Nat Subst, Shanghai 200032, Peoples R China

来源：

ORGANIC LETTERS | 2020年 / 22卷 / 19期

基金：

中国国家自然科学基金;

关键词：

HYDROGEN-ATOM; FUNCTIONALIZATION; BONDS; ALKYLATION;

D O I：

10.1021/acs.orglett.0c02475

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein we disclose a metal-free, N/O-centered radical-promoted Minisci reaction, in which the coupling of various heteroarenes with simple alkanes proceeds under mild conditions. The reaction conditions are neutral; no extra acid is added to preactivate N-heteroarenes in the Minisci reaction. The N-/O-centered radicals are generated directly from amide (TsNHMe) or alcohol (CF3CH2OH) under visible-light irradiation. This green and eco-friendly synthetic process may find potential use in medicinal chemistry.

引用

页码：7450 / 7454

页数：5

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