Engagement of TLR signaling as adjuvant: Towards smarter vaccine and beyond

被引：109

作者：

Lahiri, Amit

Das, Priyanka

Chakravortty, Dipshikha ^{[1
]}

机构：

[1] Indian Inst Sci, Dept Microbiol & Cell Biol, Ctr Infect Dis Res, Bangalore 560012, Karnataka, India

来源：

VACCINE | 2008年 / 26卷 / 52期

关键词：

Vaccination; Adjuvant; Toll like receptor; Antigen presentation; CD4 T cell response; CD8 T cell response; Immune memory; Cytokine;

D O I：

10.1016/j.vaccine.2008.09.045

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Toll like receptors (TLRs) are a family of conserved pattern recognition receptors that recognizes specific microbial patterns and allow the cell to distinguish between self and non-self materials. The very property of the TLRs to link innate and adaptive immunity offers a novel prospect to develop vaccines engaging TLR signaling. The presence of TLR ligands as adjuvant in Conjunction with the vaccine is shown to increase the efficacy and response to the immunization with a particular antigen. For infectious as well as for noninfectious diseases, TLR activation have been used in both established and experimental vaccines. The choice of the TLR agonist to be used, the subsequent efficacy and the safety profile of the vaccine is thus a crucial step in vaccine development. Recent studies also Suggest the involvement of other non-TLR immune receptors to control vaccine immunogenicity. Here we focus on the findings dealing with TLR ligands as adjuvant and discuss the importance of these studies to develop an optimal vaccine (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：6777 / 6783

页数：7

共 83 条

[1] Dendritic cell (DC) based therapy for cervical cancer:: use of DC pulsed with tumour lysate and matured with a novel synthetic clinically non-toxic double stranded RNA analogue poly [I]:poly [C12U] (Ampligen®) [J].