Overcoming immunosuppression as a new immunotherapeutic approach against pancreatic cancer

被引：25
作者：
Bazhin, Alexandr V. [1 ]
Bayry, Jagadeesh [2 ]
Umansky, Viktor [3 ,4 ]
Werner, Jens [1 ]
Karakhanova, Svetlana [1 ]
机构：
[1] Heidelberg Univ, Dept Gen Surg, Heidelberg, Germany
[2] Ctr Rech Cordeliers, INSERM Unite 872, Paris, France
[3] German Canc Res Ctr, Skin Canc Unit, Heidelberg, Germany
[4] Heidelberg Univ, Univ Med Ctr Mannheim, Dept Dermatol Venereol & Allergol, Mannheim, Germany
来源：
ONCOIMMUNOLOGY | 2013年 / 2卷 / 09期
关键词：
immunosuppression; immunotherapy; pancreatic cancer; regulatory T cells; ADENOCARCINOMA; CARCINOMA; SURVIVAL; MODEL;
D O I：
10.4161/onci.25736
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest types of malignancy. Via a broad stimulation of the immune system, PDAC activates both antitumor immune responses and immunosuppressive mechanisms. we propose that new immunotherapeutic strategies for the management of PDAC should be designed to specifically neutralize the immunosuppressive tumor microenvironment.
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