Gender and Associated Skeletal Abnormalities in Fetuses with Neural Tube Defects

被引：3

作者：

Kitova, Tanya Todorova ^{[1
]}

Karaslavova, Emilia ^{[2
]}

Gaigi, Soumeya Siala ^{[3
]}

机构：

[1] Med Univ Plovdiv, Plovdiv, Bulgaria

[2] Paisij Hilendarski Univ Plovdiv, Fac Biol, Plovdiv, Bulgaria

[3] Ctr Matern & Neonatol, Dept Fetopathol & Embryol, Tunis, Tunisia

来源：

FETAL AND PEDIATRIC PATHOLOGY | 2013年 / 32卷 / 05期

关键词：

neural tube defects (NTD); gender; skeletal abnormalities; palate; syndactyly; corpus callosum; macrocrania; CONGENITAL-ANOMALIES; POLYMORPHISM; PREVALENCE; MTHFR; GENE;

D O I：

10.3109/15513815.2013.768735

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Objective: To determine the association between gender and skeletal defects in fetuses with NTDs. Methods: 150 NTD fetuses have been examined in three years' course (01.2006-01.2009) in the Clinic of Fetopathology at the Center for Maternity and Neonatology, Tunis. Results: The most common gender associated anomalies for males are cleft palate, anomalies in the form and attachment of the outer ear and the agenesis of corpus callosum. For women, they are distortions of the spine and "frog" face. Conclusion: The proven associations in the study are important indicators in the purposeful search for NTDs in early prenatal ultrasound diagnosis.

引用

页码：326 / 336

页数：11

共 11 条

[1] Abnormal folate metabolism and genetic polymorphism of the folate pathway in a child with Down syndrome and neural tube defect
Al-Gazali, LI
Padmanabhan, R
Melnyk, S
Yi, P
Pogribny, IP
Pogribna, M
Bakir, M
Hamid, ZA
Abdulrazzaq, Y
Dawodu, A
James, SJ
[J]. AMERICAN JOURNAL OF MEDICAL GENETICS, 2001, 103 (02): : 128 - 132
[2] Serum vitamin B12 and homocysteine levels in pregnant women with neural tube defect
Ceyhan, Seyit T.
Beyan, Cengiz
Atay, Vedat
Yaman, Halil
Alanbay, Ibrahim
Kaptan, Kuersat
Baser, Iskender
[J]. GYNECOLOGICAL ENDOCRINOLOGY, 2010, 26 (08) : 578 - 581
[3] Folate levels and N5,N10-methylenetetrahydrofolate reductase genotype (MTHFR) in mothers of offspring with neural tube defects:: A case-control study
de Villarreal, LEM
Delgado-Enciso, I
Valdéz-Leal, R
Ortíz-López, R
Rojas-Martínez, A
Limón-Benavides, C
Sánchez-Peña, MA
Ancer-Rodríguez, J
Barrera-Saldaña, HA
Villarreal-Pérez, JZ
[J]. ARCHIVES OF MEDICAL RESEARCH, 2001, 32 (04) : 277 - 282
[4] The Prevalence of Congenital Anomalies in Europe
Dolk, Helen
Loane, Maria
Garne, Ester
[J]. RARE DISEASES EPIDEMIOLOGY, 2010, 686 : 349 - 364
[5] Effects of hyperinsulinemia and obesity on risk of neural tube defects among Mexican Americans
Hendricks, KA
Nuno, OM
Suarez, L
Larsen, R
[J]. EPIDEMIOLOGY, 2001, 12 (06) : 630 - 635
[6] Neural tube defects in the sample of genetic counselling
Joo, Jozsef Gabor
Beke, Artur
Papp, Csaba
Toth-Pal, Erno
Csaba, Akos
Szigeti, Zsanett
Papp, Zoltan
[J]. PRENATAL DIAGNOSIS, 2007, 27 (10) : 912 - 921
[7] Evaluation of the MTHFR C677T allele and the MTHFR gene locus in a German spina bifida population
Koch, MC
Stegmann, K
Ziegler, A
Schröter, B
Ermert, A
[J]. EUROPEAN JOURNAL OF PEDIATRICS, 1998, 157 (06) : 487 - 492
[8] Screening of the C677T mutation on the methylenetetrahydrofolate reductase gene in French patients with neural tube defects
Mornet, E
Muller, F
LenvoiseFuret, A
Delezoide, AL
Col, JY
SimonBouy, B
Serre, JL
[J]. HUMAN GENETICS, 1997, 100 (5-6) : 512 - 514
[9] Sallout Bahauddin I, 2008, Ann Saudi Med, V28, P272
[10] Methylenetetrahydrofolate reductase C677T polymorphism and pregnancy complications
Stonek, Felix
Hafner, Erich
Philipp, Karl
Hefler, Lukas A.
Bentz, Eva-Katrin
Tempfer, Clemens B.
[J]. OBSTETRICS AND GYNECOLOGY, 2007, 110 (02) : 363 - 368

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