The role of ISAba1 in expression of OXA carbapenemase genes in Acinetobacter baumannii

被引：614
作者：
Turton, JF
Ward, ME
Woodford, N
Kaufmann, ME
Pike, R
Livermore, DM
Pitt, TL
机构：
[1] Hlth Protect Agcy, Ctr Infect, Lab HealthCare Associated Infect, London NW9 5EQ, England
[2] Hlth Protect Agcy, Ctr Infect, Antibiot Resistance Monitoring & Reference Lab, London, England
来源：
FEMS MICROBIOLOGY LETTERS | 2006年 / 258卷 / 01期
关键词：
insertion sequence; Acinetobacter baumannii; OXA carbapenemase;
D O I：
10.1111/j.1574-6968.2006.00195.x
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
ISAba1 was found in all widespread clones of Acinetobacter baumannii in the United Kingdom. All isolates studied had a bla(OXA-51-like) carbapenemase gene; some also had bla(OXA-23-like) and/or bla(OXA-58-like). Among isolates with bla(OXA-51-like) as sole carbapenemase gene, only those with ISAba1 adjacent to bla(OXA-51-like) were carbapenem resistant. Minor differences in bla(OXA-51-like) sequence were observed in resistant and susceptible isolates. Isolates with bla(OXA-23-like) in addition were consistently resistant to carbapenems; in all of these ISAba1 lay upstream of bla(OXA-23-like), but was not associated with bla(OXA-51-like). These results suggest that ISAba1 is providing the promoter for bla(OXA-51-like) and, probably, for bla(OXA-23-like).
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页码：72 / 77
页数：6
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