Chromosome 9p21.3 is associated with early-onset coronary heart disease in the Irish population

被引：21

作者：

Meng, Weihua ^{[1
]}

Hughes, Anne E. ^{[1
]}

Patterson, Chris C. ^{[1
]}

Belton, Christine ^{[1
]}

Kee, Frank ^{[1
]}

McKeown, Pascal P. ^{[1
,2
]}

机构：

[1] Queens Univ Belfast, Inst Clin Sci, Ctr Clin & Populat Sci, Belfast BT12 6BJ, Antrim, North Ireland

[2] Royal Victoria Hosp, Reg Med Cardiol Ctr, Belfast BT12 6BA, Antrim, North Ireland

来源：

DISEASE MARKERS | 2008年 / 25卷 / 02期

基金：

英国经济与社会研究理事会;

关键词：

Coronary heart disease; chromosome; 9p21.3; genetics;

D O I：

10.1155/2008/375617

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Coronary heart disease (CHD) remains a leading cause of death across the world. A region on chromosome 9p21.3 has been recently reported to be associated with CHD. We evaluated 3 SNPs and 3 common haplotypes in the 9p21.3 region in 1494 individuals from 580 Irish families, where at least 1 member had early-onset (males <= 55yr, females <= 60yr) CHD. Genotypes were determined by multiplex SNaPshot technology. Using the combined TDT/ S-TDT test, the 3 single nucleotide polymorphisms (SNP), rs10757274, rs2383206 and rs1333049, were strongly associated with early-onset CHD (p = 2.7 x 10(-6), 2.7 x 10(-6), 3.8 x 10(-7), respectively). Analysis of haplotypes by the TRANSMIT program also showed that the GGC haplotype was associated with early-onset CHD (p = 7.9 x 10(-7)). In conclusion, using a family-based approach in the Irish population, we have confirmed previous reports of association between a region on chromosome 9p21.3 and early-onset CHD.

引用

页码：81 / 85

页数：5

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