A novel fluorescent "Turn-Off/Turn-On" system for the detection of acid phosphatase activity

被引：28
|
作者：
Guo, Pu [1 ]
Yan, Shengyong [1 ]
Zhou, Yimin [1 ]
Wang, Changcheng [1 ]
Xu, Xiaowei [1 ]
Weng, Xiaocheng [1 ]
Zhou, Xiang [1 ,2 ]
机构：
[1] Wuhan Univ, Coll Chem & Mol Sci, Key Lab Biomed Polymers, Minist Educ, Wuhan 430072, Hubei, Peoples R China
[2] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing, Peoples R China
来源：
ANALYST | 2013年 / 138卷 / 12期
基金：
美国国家科学基金会;
关键词：
ALKALINE-PHOSPHATASE; LABEL-FREE; BIOMARKERS; ASSAY;
D O I：
10.1039/c3an00375b
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Acid phosphatase (ACP) can be sensitively, conveniently and efficiently detected via a new fluorescent "Turn-Off/Turn-On" system. Inexpensive (NaPO3)(6) is carefully introduced into this system as a quencher of the aggregation-caused quenching (ACQ) probe. In our method, the limit of detection (LOD) is quite low for detecting ACP, which is an important biomarker and indication of several diseases.
引用
收藏
页码：3365 / 3367
页数：3
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