Transgenerational epigenetic inheritance: how important is it?

被引：201

作者：

Grossniklaus, Ueli ^{[1
,2
]}

Kelly, Bill ^{[3
]}

Ferguson-Smith, Anne C. ^{[4
,5
]}

Pembrey, Marcus ^{[6
,7
]}

Lindquist, Susan ^{[8
]}

机构：

[1] Univ Zurich, Inst Plant Biol, CH-8008 Zurich, Switzerland

[2] Univ Zurich, Zurich Basel Plant Sci Ctr, CH-8008 Zurich, Switzerland

[3] Emory Univ, Dept Biol, Atlanta, GA 30322 USA

[4] Univ Cambridge, Dept Physiol Dev & Neurosci, Cambridge CB2 3EG, England

[5] Univ Cambridge, Ctr Trophoblast Res, Cambridge CB2 3EG, England

[6] UCL, Inst Child Hlth, Clin & Mol Genet Unit, London WC1N 1EH, England

[7] Univ Bristol, Avon Longitudinal Study Parents & Children, Sch Social & Community Med, Bristol BS8 2BN, Avon, England

[8] MIT, Nine Cambridge Ctr, Whitehead Inst Biomed Res, Howard Hughes Med Inst, Cambridge, MA 02142 USA

来源：

NATURE REVIEWS GENETICS | 2013年 / 14卷 / 03期

基金：

瑞士国家科学基金会; 英国惠康基金; 欧洲研究理事会; 英国医学研究理事会;

关键词：

DNA METHYLATION; YEAST PRION; GENETIC-VARIATION; MEMORY; RNA; GERMLINE; STRESS; NUTRITION; MECHANISM; PIRNAS;

D O I：

10.1038/nrg3435

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Much attention has been given to the idea of transgenerational epigenetic inheritance, but fundamental questions remain regarding how much takes place and the impact that this might have on organisms. We asked five leading researchers in this area working on a range of model organisms and in human disease for their views on these topics. Their responses highlight the mixture of excitement and caution that surrounds transgenerational epigenetic inheritance and the wide gulf between species in terms of our knowledge of the mechanisms that may be involved.

引用

页码：228 / 235

页数：8

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