Clarifying of the potential mechanism of Sinisan formula for treatment of chronic hepatitis by systems pharmacology method

被引：28

作者：

Shu, Zhiming ^{[1
]}

Wang, He ^{[1
]}

Shahen, Mohamed ^{[1
,2
]}

Guo, Zihu ^{[1
]}

Shu, Jia ^{[1
]}

Wu, Tiantian ^{[1
]}

Bian, Xiaoyu ^{[1
]}

Shar, Akhtar Hussain ^{[1
]}

Farag, Mayada Ragab ^{[3
]}

Alagawany, Mahmoud ^{[4
]}

Liu, Chaobin ^{[5
]}

机构：

[1] Northwest A&F Univ, Coll Life Sci, Yangling 712100, Shaanxi, Peoples R China

[2] Tanta Univ, Zool Dept, Fac Sci, Tanta 31527, Egypt

[3] Zagazig Univ, Vet Med Fac, Forens Med & Toxicol Dept, Zagazig 44511, Egypt

[4] Zagazig Univ, Fac Agr, Dept Poultry, Zagazig 44511, Egypt

[5] Northwest A&F Univ, Coll Forestry, Yangling 712100, Shaanxi, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2018年 / 100卷

关键词：

Network pharmacology; Chronic hepatitis; Sinisan formula; Herbal medicines; PROLIFERATOR-ACTIVATED RECEPTOR; SI-NI-SAN; HEPATOCELLULAR-CARCINOMA; LIPID-METABOLISM; NETWORK PHARMACOLOGY; SIGNALING PATHWAY; IMMUNE-RESPONSE; BETA-SITOSTEROL; LIVER-INJURY; CELLS;

D O I：

10.1016/j.biopha.2018.02.047

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Chronic hepatitis is a general designation class of diseases, which results in different degrees of liver necrosis and inflammatory reaction, followed by liver fibrosis, may eventually develop into cirrhosis. However, the molecular pathogenesis of chronic hepatitis is too complex to elucidate. Herbal medicines, featured with multiple targets and compounds, have long displayed therapeutic effect in treating chronic hepatitis, though their molecular mechanisms of contribution remain indistinct. This research utilized the network pharmacology to confirm the molecular pathogenesis of chronic hepatitis through providing a comprehensive analysis of active chemicals, drug targets and pathways' interaction of Sinisan formula for treating chronic hepatitis. The outcomes showed that 80 active ingredients of Sinisan formula interacting with 91 therapeutic proteins were authenticated. Sinisan formula potentially participates in immune modulation, anti-inflammatory and antiviral activities, even has regulating effects on lipid metabolism. These mechanisms directly or indirectly are involved in curing chronic hepatitis by an interaction way. The network pharmacology based analysis demonstrated that Sinisan has multi-scale curative activity in regulating chronic hepatitis related biological processes, which provides a new potential way for modern medicine in the treatment of chronic diseases.

引用

页码：532 / 550

页数：19

共 77 条

[1] Nonalcoholic fatty liver disease [J].

Brunt, Elizabeth M. ;

Wong, Vincent W. -S. ;

Nobili, Valerio ;

Day, Christopher P. ;

Sookoian, Silvia ;

Maher, Jacquelyn J. ;

Bugianesi, Elisabetta ;

Sirlin, Claude B. ;

Neuschwander-Tetri, BrentA. ;

Rinella, Mary E. .

NATURE REVIEWS DISEASE PRIMERS, 2015, 1

[2] Symptoms and signs of acute alcoholic hepatitis [J].

Basra, Gurjot ;

Basra, Sarpreet ;

Parupudi, Sreeram .

WORLD JOURNAL OF HEPATOLOGY, 2011, 3 (05) :118-120

[3] Estrogen Signals Through Peroxisome Proliferator-Activated Receptor - γ Coactivator 1α to Reduce Oxidative Damage Associated With Diet-Induced Fatty Liver Disease [J].

Besse-Patin, Aurele ;

Leveille, Melissa ;

Oropeza, Daniel ;

Nguyen, Bich N. ;

Prat, Annik ;

Estall, Jennifer L. .

GASTROENTEROLOGY, 2017, 152 (01) :243-256

[4] Activity-guided isolation of constituents of Tephrosia purpurea with the potential to induce the Phase II enzyme, quinone reductase [J].

Chang, LC ;

Gerhauser, C ;

Song, L ;

Farnsworth, NR ;

Pezzuto, JM ;

Kinghorn, AD .

JOURNAL OF NATURAL PRODUCTS, 1997, 60 (09) :869-873

[5] Long-Term Entecavir Therapy Results in the Reversal of Fibrosis/Cirrhosis and Continued Histological Improvement in Patients with Chronic Hepatitis B [J].

Chang, Ting-Tsung ;

Liaw, Yun-Fan ;

Wu, Shun-Sheng ;

Schiff, Eugene ;

Han, Kwang-Hyub ;

Lai, Ching-Lung ;

Safadi, Rifaat ;

Lee, Samuel S. ;

Halota, Waldemar ;

Goodman, Zachary ;

Chi, Yun-Chan ;

Zhang, Hui ;

Hindes, Robert ;

Iloeje, Uchenna ;

Beebe, Suzanne ;

Kreter, Bruce .

HEPATOLOGY, 2010, 52 (03) :886-893

[6] Effect of traditional Chinese medicine formula Sinisan on chronic restraint stressinduced nonalcoholic fatty liver disease: a rat study [J].

Cheng, Fafeng ;

Ma, Chongyang ;

Wang, Xueqian ;

Zhai, Changming ;

Wang, Guoli ;

Xu, Xiaolin ;

Mu, Jie ;

Li, Changxiang ;

Wang, Zisong ;

Zhang, Xiaoyu ;

Yue, Wenchao ;

Du, Xin ;

Lian, Yajun ;

Zhu, Wenxiang ;

Yin, Xiangjun ;

Wei, Zhen ;

Song, Wenjie ;

Wang, Qingguo .

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2017, 17

[7] Suppression of hepatitis B virus-derived human hepatocellular carcinoma by NF-κB-inducing kinase-specific siRNA using liver-targeting liposomes [J].

Cho, Hyun-Ah ;

Park, In-Sung ;

Kim, Tae-Woo ;

Oh, Yu-Kyoung ;

Yang, Ki-Sook ;

Kim, Jin-Seok .

ARCHIVES OF PHARMACAL RESEARCH, 2009, 32 (07) :1077-1086

[8]

Choi YH, 2003, INT J ONCOL, V23, P1657

[9] Pomegranate protects against arsenic-induced p53-dependent ROS-mediated inflammation and apoptosis in liver cells [J].

Choudhury, Sreetama ;

Ghosh, Sayan ;

Mukherjee, Sudeshna ;

Gupta, Payal ;

Bhattacharya, Saurav ;

Adhikary, Arghya ;

Chattopadhyay, Sreya .

JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2016, 38 :25-40

[10] Stop codons in the hepatitis B surface proteins are enriched during antiviral therapy and are associated with host cell apoptosis [J].

Colledge, Danielle ;

Soppe, Sally ;

Yuen, Lilly ;

Selleck, Lucy ;

Walsh, Renae ;

Locarnini, Stephen ;

Warner, Nadia .

VIROLOGY, 2017, 501 :70-78

← 1 2 3 4 5 6 7 8 →