Self-Assemblies and In Vitro Cancer Inhibition of Peptide Based Nanocomplexes

As an inspiration of biological systems, here we report the in vitro anticancer studies of peptide bound metal nanocomplexes. In addition to offer modern ways of building functionalized nanoparticle systems, this work provides an experimental proof that a single peptide molecule is sufficient for the immobilization of a nanoparticle. Here, these peptide assembled nanocomplexes are synthesized through a phase transfer route. The surface plasmon band shift due to the interaction of the peptide with the metal nanoparticles predicts the formation of nanocomplexes. Additional spectral, thermal and morphological characterizations of the products reassure their creation. All the nanocomplexes are well documented for their in vitro anticancer potencies against Ehrlich ascites carcinoma tumor model and three human cancer cell lines. The anticancer mechanism of our nanocomplexes has been documented from their enhanced DNA splitting personalities under physiological conditions. Moreover, all the nanocomplexes show good antimicrobial actions against few bacterial and fungal strains.