Effective synthetic routes to activated pyrrolo[3,2,1-hi]indoles

被引：10
|
作者：
Jumina [1 ]
Keller, Paul A. [1 ]
Kumar, Naresh [1 ]
Black, David Stc. [1 ]
机构：
[1] Univ New S Wales, Sch Chem, Sydney, NSW 2052, Australia
来源：
TETRAHEDRON | 2008年 / 64卷 / 51期
基金：
澳大利亚研究理事会;
关键词：
Indoles; Pyrroloindoles; Aldol reaction; Cyclisation reactions;
D O I：
10.1016/j.tet.2008.10.025
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Pyrrolo[3,2,1-hi]indoles have been formed by the aldol cyclisation of 7-formyl-N-indolylacetates. The synthetic sequence incorporates three steps from suitably activated indoles: these are alkylation at nitrogen with a bromoacetic ester, formylation at C7 and an aldol condensation between these two substituents. Art X-ray crystal structure of pyrrolo[3,2,1-hi]indole 24 is described. Crown Copyright (C) 2008 Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：11603 / 11610
页数：8
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