Essential flexibility in the T-cell recognition of antigen

被引：287
作者：
Kersh, GJ [1 ]
Allen, PM [1 ]
机构：
[1] WASHINGTON UNIV,SCH MED,DEPT PATHOL,ST LOUIS,MO 63110
来源：
NATURE | 1996年 / 380卷 / 6574期
关键词：
D O I：
10.1038/380495a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
alpha beta T cells specifically recognize a ligand composed of a peptide bound to a self-major-histocompatibility-complex molecule, but the recognition of slightly altered ligands by T cells can lead to a partial activation. This flexibility is crucial for T-cell development and can have both beneficial and harmful effects on peripheral T cells.
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收藏
页码：495 / 498
页数：4
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