Genetic Markers of Inflammation and Their Role in Cardiovascular Disease

被引：45
作者：
Raman, Kripa [1 ,2 ,3 ,4 ]
Chong, Michael [1 ,2 ,3 ]
Akhtar-Danesh, Gileh-Gol [1 ,2 ,3 ]
D'Mello, Matthew [1 ,2 ,3 ]
Hasso, Ranya [1 ,2 ,3 ]
Ross, Stephanie [1 ,2 ,5 ]
Xu, Fangzhou [1 ,2 ,3 ]
Pare, Guillaume [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada
[2] McMaster Univ, Hamilton, ON L8L 2X2, Canada
[3] Hamilton Hlth Sci, Thrombosis & Atherosclerosis Res Inst, Hamilton, ON, Canada
[4] McMaster Univ, Fac Hlth Sci, Dept Pathol & Mol Med, Hamilton, ON L8L 2X2, Canada
[5] McMaster Univ, Fac Hlth Sci, Dept Clin Epidemiol & Biostat, Populat Genom Program, Hamilton, ON L8L 2X2, Canada
来源：
CANADIAN JOURNAL OF CARDIOLOGY | 2013年 / 29卷 / 01期
关键词：
C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; INTERCELLULAR-ADHESION MOLECULE-1; HUMAN ENDOTHELIAL-CELLS; MYOCARDIAL-INFARCTION; P-SELECTIN; CRP GENE; MENDELIAN RANDOMIZATION; PLASMA-CONCENTRATIONS; SOLUBLE RECEPTOR;
D O I：
10.1016/j.cjca.2012.06.025
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Atherosclerosis and associated cardiovascular diseases (CVD) are multifaceted disorders, influenced by environmental and heritable risk factors. Inflammation plays a significant role in each stage of atherosclerosis and as such, discovery and characterization of inflammatory biomarkers associated with risk of CVD is an active area of research. Because of the strong predicted genetic components of both CVD and inflammatory biomarkers, there is interest in identifying genetic determinants of inflammatory markers and characterizing their role in CVD. Recent developments in the methodological approaches of genetic epidemiology, especially genome-wide association studies and Mendelian randomization studies, have been effective in identifying novel gene associations and determining the causality of these genes with CVD. In this review, we will summarize the current understanding of the genetic architecture of inflammatory markers. The markers selected for this review include C-reactive protein, soluble intercellular adhesion molecule-1, interleukin-6, and P-selectin.
引用
收藏
页码：67 / 74
页数：8
相关论文
共 64 条
[1]  
[Anonymous], 2008, PLOS GENET
[2]   Large-scale genomic studies reveal central role of ABO in sP-selectin and sICAM-1 levels [J].
Barbalic, Maja ;
Dupuis, Josee ;
Dehghan, Abbas ;
Bis, Joshua C. ;
Hoogeveen, Ron C. ;
Schnabel, Renate B. ;
Nambi, Vijay ;
Bretler, Monique ;
Smith, Nicholas L. ;
Peters, Annette ;
Lu, Chen ;
Tracy, Russell P. ;
Aleksic, Nena ;
Heeriga, Jan ;
Keaney, John F., Jr. ;
Rice, Kenneth ;
Lip, Gregory Y. H. ;
Vasan, Ramachandran S. ;
Glazer, Nicole L. ;
Larson, Martin G. ;
Uitterlinden, Andre G. ;
Yamamoto, Jennifer ;
Durda, Peter ;
Haritunians, Talin ;
Psaty, Bruce M. ;
Boerwinkle, Eric ;
Hofman, Albert ;
Koenig, Wolfgang ;
Jenny, Nancy S. ;
Witteman, Jacqueline C. ;
Ballantyne, Christie ;
Benjamin, Emelia J. .
HUMAN MOLECULAR GENETICS, 2010, 19 (09) :1863-1872
[3]   Apolipoproteins modulate the inflammatory response to lipopolysaccharide [J].
Berbée, JFP ;
Havekes, LM ;
Rensen, PCN .
JOURNAL OF ENDOTOXIN RESEARCH, 2005, 11 (02) :97-103
[4]   Possible protective role for c-reactive protein in atherogenesis - Complement activation by modified lipoproteins halts before detrimental terminal sequence [J].
Bhakdi, S ;
Torzewski, M ;
Paprotka, K ;
Schmitt, S ;
Barsoom, H ;
Suriyaphol, P ;
Han, SR ;
Lackner, KJ ;
Husmann, M .
CIRCULATION, 2004, 109 (15) :1870-1876
[5]   The adhesion molecule P-selectin and cardiovascular disease [J].
Blann, AD ;
Nadar, SK ;
Lip, GYH .
EUROPEAN HEART JOURNAL, 2003, 24 (24) :2166-2179
[6]   The influence of age, gender and ABO blood group on soluble endothelial cell markers and adhesion molecules [J].
Blann, AD ;
Daly, RJ ;
Amiral, J .
BRITISH JOURNAL OF HAEMATOLOGY, 1996, 92 (02) :498-500
[7]   C-reactive protein binds to both oxidized LDL and apoptotic cells through recognition of a common ligand: Phosphorylcholine of oxidized phospholipids [J].
Chang, MK ;
Binder, CJ ;
Torzewski, M ;
Witztum, JL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (20) :13043-13048
[8]   Induction of leptin resistance through direct interaction of C-reactive protein with leptin [J].
Chen, K ;
Li, FH ;
Li, J ;
Cai, HB ;
Strom, S ;
Bisello, A ;
Kelley, DE ;
Friedman-Einat, M ;
Skibinski, GA ;
McCrory, MA ;
Szalai, AJ ;
Zhao, AZ .
NATURE MEDICINE, 2006, 12 (04) :425-432
[9]   P-selectin or intercellular adhesion molecule (ICAM)-1 deficiency substantially protects against atherosclerosis in apolipoprotein E-deficient mice [J].
Collins, RG ;
Velji, R ;
Guevara, NV ;
Hicks, MJ ;
Chan, L ;
Beaudet, AL .
JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (01) :189-194
[10]   Plasma leptin concentrations: gender differences and associations with metabolic risk factors for cardiovascular disease [J].
Couillard, C ;
Mauriege, P ;
Prudhomme, D ;
Nadeau, A ;
Tremblay, A ;
Bouchard, C ;
Despres, JP .
DIABETOLOGIA, 1997, 40 (10) :1178-1184
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