Convergent differentiation: myeloid and lymphoid pathways to murine plasmacytoid dendritic cells

被引：96
作者：
Sathe, Priyanka [1 ,2 ,3 ,4 ]
Vremec, David [1 ]
Wu, Li [1 ,5 ]
Corcoran, Lynn [1 ]
Shortman, Ken [1 ,2 ]
机构：
[1] Walter & Eliza Hall Inst Med Res, Parkville, Vic, Australia
[2] Univ Melbourne, Dept Med Biol, Parkville, Vic 3052, Australia
[3] Mt Sinai Sch Med, Dept Oncol Sci, New York, NY USA
[4] Mt Sinai Sch Med, Inst Immunol, New York, NY USA
[5] Tsinghua Univ, Tsinghua Peking Univ, Sch Med, Joint Ctr Life Sci, Beijing 100084, Peoples R China
来源：
BLOOD | 2013年 / 121卷 / 01期
基金：
英国医学研究理事会;
关键词：
TRANSCRIPTION FACTOR E2-2; CUTTING EDGE; PROGENITORS; PRECURSORS; IDENTIFICATION; ACTIVATION; GENERATION; ALPHA; NODES;
D O I：
10.1182/blood-2012-02-413336
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The developmental origin of IFN-producing plasmacytoid dendritic cells (pDCs) has been uncertain. In the present study, we tracked the development of pDCs in cultures of BM precursors stimulated with Flt3 ligand. Common myeloid precursors (CMPs) produced both conventional DCs (cDCs) and pDCs via the DC-restricted common DC precursor. Common lymphoid precursors (CLPs) produced only a few cDCs with variable efficiency, but produced pDCs via a transient intermediate precursor with B-cell potential. The pDCs of both origins produced IFN-alpha when stimulated with CpG oligonucleotides. The pDCs of CLP origin showed evidence of past RAG1 expression and had D-J rearrangements in IgH genes. Most pDCs and all cDCs of CMP origin lacked these signs of a lymphoid past. However, in these cultures, some pDCs of CMP origin showed evidence of past RAG1 expression and had D-J IgH gene rearrangements; most of these derived from a subset of CMPs already expressing RAG1. (Blood. 2013; 121(1):11-19)
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收藏
页码：11 / 19
页数：9
相关论文
共 27 条
  • [1] A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
    Akashi, K
    Traver, D
    Miyamoto, T
    Weissman, IL
    [J]. NATURE, 2000, 404 (6774) : 193 - 197
  • [2] Plasmacytoid Dendritic Cell Dichotomy: Identification of IFN-α Producing Cells as a Phenotypically and Functionally Distinct Subset
    Bjoerck, Pia
    Leong, H. Xianne
    Engleman, Edgar G.
    [J]. JOURNAL OF IMMUNOLOGY, 2011, 186 (03) : 1477 - 1485
  • [3] Generation of murine dendritic cells from flt3-ligand-supplemented bone marrow cultures
    Brasel, K
    De Smedt, T
    Smith, JL
    Maliszewski, CR
    [J]. BLOOD, 2000, 96 (09) : 3029 - 3039
  • [4] Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development
    Cisse, Babacar
    Caton, Michele L.
    Lehner, Manfred
    Maeda, Takahiro
    Scheu, Stefanie
    Locksley, Richard
    Holmberg, Dan
    Zweier, Christiane
    den Hollander, Nicolette S.
    Kant, Sarina G.
    Holter, Wolfgang
    Rauch, Anita
    Zhuang, Yuan
    Reizis, Boris
    [J]. CELL, 2008, 135 (01) : 37 - 48
  • [5] Plasmacytoid dendritic cells in immunity
    Colonna, M
    Trinchieri, G
    Liu, YJ
    [J]. NATURE IMMUNOLOGY, 2004, 5 (12) : 1219 - 1226
  • [6] Cutting edge:: Peyer's patch plasmacytoid dendritic cells (pDCs) produce low levels of type I interferons:: Possible role for IL-10, TGFβ, and prostaglandin E2 in conditioning a unique mucosal pDC phenotype
    Contractor, Nikhat
    Louten, Jennifer
    Kim, Leesun
    Biron, Christine A.
    Kelsall, Brian L.
    [J]. JOURNAL OF IMMUNOLOGY, 2007, 179 (05) : 2690 - 2694
  • [7] The lymphoid past of mouse plasmacytoid cells and thymic dendritic cells
    Corcoran, L
    Ferrero, I
    Vremec, D
    Lucas, K
    Waithman, J
    O'Keeffe, M
    Wu, L
    Wilson, A
    Shortman, K
    [J]. JOURNAL OF IMMUNOLOGY, 2003, 170 (10) : 4926 - 4932
  • [8] The early progenitors of mouse dendritic cells and plasmacytoid predendritic cells are within the bone marrow hemopoietic precursors expressing Flt3
    D'Amico, A
    Wu, L
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (02) : 293 - 303
  • [9] Continuous Expression of the Transcription Factor E2-2 Maintains the Cell Fate of Mature Plasmacytoid Dendritic Cells
    Ghosh, Hiyaa S.
    Cisse, Babacar
    Bunin, Anna
    Lewis, Kanako L.
    Reizis, Boris
    [J]. IMMUNITY, 2010, 33 (06) : 905 - 916
  • [10] The development of murine plasmacytoid dendritic cell precursors is differentially regulated by FLT3-ligand and granulocyte/macrophage colony-stimulating factor
    Gilliet, M
    Boonstra, A
    Paturel, C
    Antonenko, S
    Xu, XL
    Trinchieri, G
    O'Garra, A
    Liu, YJ
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (07) : 953 - 958
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