Genomes on the Edge: Programmed Genome Instability in Ciliates

被引：70

作者：

Bracht, John R. ^{[1
]}

Fang, Wenwen ^{[1
]}

Goldman, Aaron David ^{[1
]}

Dolzhenko, Egor ^{[1
]}

Stein, Elizabeth M. ^{[1
]}

Landweber, Laura F. ^{[1
]}

机构：

[1] Princeton Univ, Dept Ecol & Evolutionary Biol, Princeton, NJ 08544 USA

来源：

CELL | 2013年 / 152卷 / 03期

基金：

美国国家科学基金会;

关键词：

INTERNAL ELIMINATED SEQUENCES; DNA ELIMINATION; EUPLOTES-CRASSUS; SMALL RNAS; NUCLEAR DIFFERENTIATION; DEVELOPMENTAL EXCISION; CYTOSINE METHYLATION; H3K27; METHYLATION; SURFACE-ANTIGEN; TETRAHYMENA;

D O I：

10.1016/j.cell.2013.01.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ciliates are an ancient and diverse group of microbial eukaryotes that have emerged as powerful models for RNA-mediated epigenetic inheritance. They possess extensive sets of both tiny and long noncoding RNAs that, together with a suite of proteins that includes transposases, orchestrate a broad cascade of genome rearrangements during somatic nuclear development. This Review emphasizes three important themes: the remarkable role of RNA in shaping genome structure, recent discoveries that unify many deeply diverged ciliate genetic systems, and a surprising evolutionary "sign change" in the role of small RNAs between major species groups.

引用

页码：406 / 416

页数：11

共 106 条

[11] Marine Protistan Diversity [J].

Caron, David A. ;

Countway, Peter D. ;

Jones, Adriane C. ;

Kim, Diane Y. ;

Schnetzer, Astrid .

ANNUAL REVIEW OF MARINE SCIENCE, VOL 4, 2012, 4 :467-493

[12]

Casacuberta JM, 2003, GENE, V311, P1, DOI 10.1016/S0378-1119(03)00557-2

[13] Communication between parental and developing genomes during Tetrahymena nuclear differentiation is likely mediated by homologous RNAs [J].

Chalker, DL ;

Fuller, P ;

Yao, MC .

GENETICS, 2005, 169 (01) :149-160

[14] Nongenic, bidirectional transcription precedes and may promote developmental DNA deletion in Tetrahymena thermophila [J].

Chalker, DL ;

Yao, MC .

GENES & DEVELOPMENT, 2001, 15 (10) :1287-1298

[15] Dynamic nuclear reorganization during genome remodeling of Tetrahymena [J].

Chalker, Douglas L. .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2008, 1783 (11) :2130-2136

[16] DNA Elimination in Ciliates: Transposon Domestication and Genome Surveillance [J].

Chalker, Douglas L. ;

Yao, Meng-Chao .

ANNUAL REVIEW OF GENETICS, VOL 45, 2011, 45 :227-246

[17] The evolutionary origin of a complex scrambled gene [J].

Chang, WJ ;

Bryson, PD ;

Liang, H ;

Shin, MK ;

Landweber, LF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (42) :15149-15154

[18] A Domesticated piggyBac Transposase Plays Key Roles in Heterochromatin Dynamics and DNA Cleavage during Programmed DNA Deletion in Tetrahymena thermophila [J].

Cheng, Chao-Yin ;

Vogt, Alexander ;

Mochizuki, Kazufumi ;

Yao, Meng-Chao .

MOLECULAR BIOLOGY OF THE CELL, 2010, 21 (10) :1753-1762

[19] Tetrahymena thermophila JMJD3 Homolog Regulates H3K27 Methylation and Nuclear Differentiation [J].

Chung, Pei-Han ;

Yao, Meng-Chao .

EUKARYOTIC CELL, 2012, 11 (05) :601-614

[20] Whole Genome Studies of Tetrahymena [J].

Coyne, Robert S. ;

Stovert, Nicholas A. ;

Miao, Wei .

TETRAHYMENA THERMOPHILA, 2012, 109 :53-81

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