Genomes on the Edge: Programmed Genome Instability in Ciliates

被引：70
作者：
Bracht, John R. [1 ]
Fang, Wenwen [1 ]
Goldman, Aaron David [1 ]
Dolzhenko, Egor [1 ]
Stein, Elizabeth M. [1 ]
Landweber, Laura F. [1 ]
机构：
[1] Princeton Univ, Dept Ecol & Evolutionary Biol, Princeton, NJ 08544 USA
来源：
CELL | 2013年 / 152卷 / 03期
基金：
美国国家科学基金会;
关键词：
INTERNAL ELIMINATED SEQUENCES; DNA ELIMINATION; EUPLOTES-CRASSUS; SMALL RNAS; NUCLEAR DIFFERENTIATION; DEVELOPMENTAL EXCISION; CYTOSINE METHYLATION; H3K27; METHYLATION; SURFACE-ANTIGEN; TETRAHYMENA;
D O I：
10.1016/j.cell.2013.01.005
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ciliates are an ancient and diverse group of microbial eukaryotes that have emerged as powerful models for RNA-mediated epigenetic inheritance. They possess extensive sets of both tiny and long noncoding RNAs that, together with a suite of proteins that includes transposases, orchestrate a broad cascade of genome rearrangements during somatic nuclear development. This Review emphasizes three important themes: the remarkable role of RNA in shaping genome structure, recent discoveries that unify many deeply diverged ciliate genetic systems, and a surprising evolutionary "sign change" in the role of small RNAs between major species groups.
引用
收藏
页码：406 / 416
页数：11
相关论文
共 106 条
[1]   RNA-guided DNA assembly [J].
Angeleska, Angela ;
Jonoska, Natasa ;
Saito, Masahico ;
Landweber, Laura F. .
JOURNAL OF THEORETICAL BIOLOGY, 2007, 248 (04) :706-720
[2]   The Paramecium Germline Genome Provides a Niche for Intragenic Parasitic DNA: Evolutionary Dynamics of Internal Eliminated Sequences [J].
Arnaiz, Olivier ;
Mathy, Nathalie ;
Baudry, Celine ;
Malinsky, Sophie ;
Aury, Jean-Marc ;
Denby Wilkes, Cyril ;
Garnier, Olivier ;
Labadie, Karine ;
Lauderdale, Benjamin E. ;
Le Mouel, Anne ;
Marmignon, Antoine ;
Nowacki, Mariusz ;
Poulain, Julie ;
Prajer, Malgorzata ;
Wincker, Patrick ;
Meyer, Eric ;
Duharcourt, Sandra ;
Duret, Laurent ;
Betermier, Mireille ;
Sperling, Linda .
PLOS GENETICS, 2012, 8 (10)
[3]   Study of an RNA helicase implicates small RNA-noncoding RNA interactions in programmed DNA elimination in Tetrahymena [J].
Aronica, Lucia ;
Bednenko, Janna ;
Noto, Tomoko ;
DeSouza, Leroi V. ;
Siu, K. W. Michael ;
Loidl, Josef ;
Pearlman, Ronald E. ;
Gorovsky, Martin A. ;
Mochizuki, Kazufumi .
GENES & DEVELOPMENT, 2008, 22 (16) :2228-2241
[4]   MICRONUCLEAR GENOME ORGANIZATION IN EUPLOTES-CRASSUS - A TRANSPOSON-LIKE ELEMENT IS REMOVED DURING MACRONUCLEAR DEVELOPMENT [J].
BAIRD, SE ;
FINO, GM ;
TAUSTA, SL ;
KLOBUTCHER, LA .
MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (09) :3793-3807
[5]   PiggyMac, a domesticated piggyBac transposase involved in programmed genome rearrangements in the ciliate Paramecium tetraurelia [J].
Baudry, Celine ;
Malinsky, Sophie ;
Restituito, Matthieu ;
Kapusta, Aurelie ;
Rosa, Sarah ;
Meyer, Eric ;
Betermier, Mireille .
GENES & DEVELOPMENT, 2009, 23 (21) :2478-2483
[6]   TANDEMLY REPEATED SEQUENCE AT TERMINI OF EXTRACHROMOSOMAL RIBOSOMAL-RNA GENES IN TETRAHYMENA [J].
BLACKBURN, EH ;
GALL, JG .
JOURNAL OF MOLECULAR BIOLOGY, 1978, 120 (01) :33-53
[7]   An anaerobic mitochondrion that produces hydrogen [J].
Boxma, B ;
de Graaf, RM ;
van der Staay, GWM ;
van Alen, TA ;
Ricard, G ;
Gabaldón, T ;
van Hoek, AHAM ;
Moon-van der Staay, SY ;
Koopman, WJH ;
van Hellemond, JJ ;
Tielens, AGM ;
Friedrich, T ;
Veenhuis, M ;
Huynen, MA ;
Hackstein, JHP .
NATURE, 2005, 434 (7029) :74-79
[8]   Cytosine methylation and hydroxymethylation mark DNA for elimination in Oxytricha trifallax [J].
Bracht, John R. ;
Perlman, David H. ;
Landweber, Laura F. .
GENOME BIOLOGY, 2012, 13 (10) :R99
[9]   Tetrahymena histone acetyltransferase A: A homolog to yeast Gcn5p linking histone acetylation to gene activation [J].
Brownell, JE ;
Zhou, JX ;
Ranalli, T ;
Kobayashi, R ;
Edmondson, DG ;
Roth, SY ;
Allis, CD .
CELL, 1996, 84 (06) :843-851
[10]   RNase III enzymes and the initiation of gene silencing [J].
Carmell, MA ;
Hannon, GJ .
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2004, 11 (03) :214-218
12345678910