Facile synthesis of PDMAEMA-coated hollow mesoporous silica nanoparticles and their pH-responsive controlled release

被引：54
作者：
Yu, Faqi [1 ]
Tang, Xinde [2 ]
Pei, Meishan [1 ]
机构：
[1] Univ Jinan, Sch Chem & Chem Engn, Jinan 250022, Peoples R China
[2] Shandong Jiaotong Univ, Sch Mat Sci & Engn, Jinan 250023, Peoples R China
来源：
MICROPOROUS AND MESOPOROUS MATERIALS | 2013年 / 173卷
关键词：
Hollow mesoporous silica nanoparticles; Stimuli-responsive polymer; Surface-initiated atom transfer radical polymerization; Storage capacity; pH-responsive controlled release; MESOSTRUCTURED SILICA; DRUG-DELIVERY; FABRICATION; SPHERES; SYSTEM; INTERFACE; NANORODS; POLYMER;
D O I：
10.1016/j.micromeso.2013.02.012
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A versatile method of grafting poly(N,N-dimethylaminoethyl methacrylate) (PDMAEMA) on the surface of hollow mesoporous silica nanoparticles (HMSN) via surface-initiated atom transfer radical polymerization (SI-ATRP) has been presented. TEM, FT-IR, TGA, XRD, and N-2 adsorption-desorption analysis were used for the characterization. The results state that the stimuli-responsive polymer has been successfully grafted onto the surface of HMSN. These hybrid nanoparticles have been proven to have a large storage capacity which can be applied in drug delivery. The external coated PDMAEMA layers act as a storage gate as well as a release switch in response to the stimuli of environment. In this paper, pH-responsive controlled release behavior was focused. (c) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码：64 / 69
页数：6
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