Formal Carbene C-H Bond Insertion in the Cu(I)-Catalyzed Reaction of Bis(trimethylsilyl)diazomethane with Benzoxazoles and Oxazoles

被引：23

作者：

Wang, Shuai ^{[1
,2
]}

Xu, Shuai ^{[1
,2
]}

Yang, Cheng ^{[1
,2
]}

Sun, Hanli ^{[1
,2
]}

Wang, Jianbo ^{[1
,2
,3
]}

机构：

[1] Peking Univ, Coll Chem, BNLMS, Minist Educ, Beijing 100871, Peoples R China

[2] Peking Univ, Key Lab Bioorgan Chem & Mol Engn, Minist Educ, Coll Chem, Beijing 100871, Peoples R China

[3] Chinese Acad Sci, State Key Lab Organomet Chem, Shanghai 200032, Peoples R China

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 06期

关键词：

PETERSON OLEFINATIONS; N-TOSYLHYDRAZONES; METAL CARBENE; REAGENTS; DERIVATIVES; SI;

D O I：

10.1021/acs.orglett.9b00391

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Cu(I)-catalyzed cross-coupling reaction of bis(trimethylsilyl)diazomethane and benzoxazoles/oxazoles is reported. A wide range of functional groups can be tolerated in this transformation. This reaction provides a new method to directly introduce a 1,1-bis(trimethylsilyl)methyl group into heteroaromatic C-H bonds. Subsequent transformations of 1,1-bis(trimethylsilyl)-methylated heteroaromatic compounds are also presented.

引用

页码：1809 / 1812

页数：4

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