Temperature-insensitive detection of low-concentration nanoparticles using a functionalized high-Q microcavity

被引：12

作者：

Jin, Wei-Liang ^{[1
,2
]}

Yi, Xu ^{[3
]}

Hu, Yi-Wen ^{[1
,2
]}

Li, Bei-Bei ^{[1
,2
]}

Xiao, Yun-Feng ^{[1
,2
]}

机构：

[1] Peking Univ, State Key Lab Mesoscop Phys, Beijing 100871, Peoples R China

[2] Peking Univ, Sch Phys, Beijing 100871, Peoples R China

[3] CALTECH, Dept Appl Phys, Pasadena, CA 91125 USA

来源：

APPLIED OPTICS | 2013年 / 52卷 / 02期

基金：

中国国家自然科学基金;

关键词：

WHISPERING-GALLERY MODES; RING-RESONATOR SENSORS; MICROSPHERES; SHIFT; BIOSENSOR; CAVITIES;

D O I：

10.1364/AO.52.000155

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

The ability to detect nanoparticles in extremely dilute solutions in the presence of environmental noise is crucial for biosensing applications. In this paper we propose a scheme for detecting target nanoparticles through their scattering effects in a high-Q whispering gallery microcavity. The detection signal, defined as the total linewidth broadening of the two new split modes that appear upon nanoparticle adsorption, is highly sensitive and proportional to the nanoparticle concentration. Furthermore, this new method of detection eliminates the requirement for strict temperature control and is capable of distinguishing the signal from the biorecognitions (e. g., antibodies) initially attached to the resonator and that from the target nanoparticles (e. g., antigens). (C) 2013 Optical Society of America

引用

页码：155 / 161

页数：7

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