Evolution of the receptor binding phenotype of influenza A (H5) viruses

被引：159
作者：
Gambaryan, A
Tuzikov, A
Pazynina, G
Bovin, N
Balish, A
Klimov, A
机构：
[1] Ctr Dis Control & Prevent, Influenza Branch, Atlanta, GA 30333 USA
[2] Russian Acad Med Sci, Chumakov Inst Poliomyelitis & Viral Encephalitis, Moscow 142782, Russia
[3] Russian Acad Sci, MM Shemyakin Bioorgan Chem Inst, Moscow 117997, Russia
来源：
VIROLOGY | 2006年 / 344卷 / 02期
基金：
俄罗斯基础研究基金会;
关键词：
influenza virus; hemagglutinin; receptor specificity; host range;
D O I：
10.1016/j.virol.2005.08.035
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Receptor specificity of influenza A/H5 viruses including human 2003-04 isolates was studied. All but two isolates preserved high affinity to Sia2-3Gal (avian-like) receptors. However, two isolates (February, 2003, Hong Kong) demonstrated decreased affinity to Sia2-3Gal and moderate affinity to a Sia2-6Gal (human-like) receptors. These two viruses had a unique Ser227-Asn change in the hemagglutinin molecule. Thus, a single amino acid substitution can significantly alter receptor specificity of avian H5N1 viruses, providing them with an ability to bind to receptors optimal for human influenza viruses. Asian 2003-04 H5 isolates from chickens and humans demonstrated highest affinity to the sulfated trisaccharide Neu5Ac alpha 2-3Gal beta 1-4(6-HSO3)GlcNAc beta (Su-3'SLN) receptor but, in contrast to 1997 isolates, had increased affinity to fucosylated Su-3'SLN. American poultry H5 viruses also had increased affinity to Su-3'SLN. These data demonstrate that the genetic evolution of avian influenza A(H5NI) viruses is accompanied during adaptation to poultry by the evolution of their receptor specificity. (C) 2005 Published by Elsevier Inc.
引用
收藏
页码：432 / 438
页数：7
相关论文
共 21 条
[11]   Human and avian influenza viruses target different cell types in cultures of human airway epithelium [J].
Matrosovich, MN ;
Matrosovich, TY ;
Gray, T ;
Roberts, NA ;
Klenk, HD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (13) :4620-4624
[12]   Binding of the hemagglutinin from human or equine influenza H3 viruses to the receptor is altered by substitutions at residue 193 [J].
Medeiros, R ;
Naffakh, N ;
Manuguerra, JC ;
van der Werf, S .
ARCHIVES OF VIROLOGY, 2004, 149 (08) :1663-1671
[13]   INFLUENZA-VIRUS STRAINS SELECTIVELY RECOGNIZE SIALYLOLIGOSACCHARIDES ON HUMAN RESPIRATORY EPITHELIUM - THE ROLE OF THE HOST-CELL IN SELECTION OF HEMAGGLUTININ RECEPTOR SPECIFICITY [J].
NELSON, J ;
COUCEIRO, SS ;
PAULSON, JC ;
BAUM, LG .
VIRUS RESEARCH, 1993, 29 (02) :155-165
[14]   Structure of a selectin-like mutant of mannose-binding protein complexed with sialylated and sulfated Lewis(x) oligosaccharides [J].
Ng, KKS ;
Weis, WI .
BIOCHEMISTRY, 1997, 36 (05) :979-988
[15]   Isolation and characterization of avian influenza viruses, including highly pathogenic H5N1, from poultry in live bird markets in Hanoi, Vietnam, in 2001 [J].
Nguyen, DC ;
Uyeki, TM ;
Jadhao, S ;
Maines, T ;
Shaw, M ;
Matsuoka, Y ;
Smith, C ;
Rowe, T ;
Lu, XH ;
Hall, H ;
Xu, XY ;
Balish, A ;
Klimov, A ;
Tumpey, TM ;
Swayne, DE ;
Huynh, LPT ;
Nghiem, HK ;
Nguyen, HHT ;
Hoang, LT ;
Cox, NJ ;
Katz, JM .
JOURNAL OF VIROLOGY, 2005, 79 (07) :4201-4212
[16]  
Paulson J., 1985, The receptors, VII, P131
[17]   Synthesis of complex α2-3 sialooligosaccharides, including sulfated and fucosylated ones, using Neu5Acα2-3Gal as a building block [J].
Pazynina, GV ;
Sablina, MA ;
Tuzikov, AB ;
Chinarev, AA ;
Bovin, NV .
MENDELEEV COMMUNICATIONS, 2003, (06) :245-248
[18]  
PEIRIS JS, 2004, LANCET, V363, P582
[19]   Comparisons of highly virulent H5N1 influenza A viruses isolated from humans and chickens from Hong Kong [J].
Suarez, DL ;
Perdue, ML ;
Cox, N ;
Rowe, T ;
Bender, C ;
Huang, J ;
Swayne, DE .
JOURNAL OF VIROLOGY, 1998, 72 (08) :6678-6688
[20]   Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness [J].
Subbarao, K ;
Klimov, A ;
Katz, J ;
Regnery, H ;
Lim, W ;
Hall, H ;
Perdue, M ;
Swayne, D ;
Bender, C ;
Huang, J ;
Hemphill, M ;
Rowe, T ;
Shaw, M ;
Xu, XY ;
Fukuda, K ;
Cox, N .
SCIENCE, 1998, 279 (5349) :393-396
123