Dysregulation of type I interferon responses in COVID-19

被引：321
|
作者：
Acharya, Dhiraj [1 ]
Liu, GuanQun [1 ]
Gack, Michaela U. [1 ]
机构：
[1] Univ Chicago, Dept Microbiol, Chicago, IL 60637 USA
来源：
NATURE REVIEWS IMMUNOLOGY | 2020年 / 20卷 / 07期
关键词：
D O I：
10.1038/s41577-020-0346-x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Infection with SARS-CoV-2 can lead to excessive production of pro-inflammatory cytokines, but the production of type I interferons, which are key antiviral mediators, is reportedly blunted. Here, we discuss how imbalanced interferon responses may contribute to the pathology of COVID-19.
引用
收藏
页码：397 / 398
页数：2
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