Rapidly Progressive Glomerulonephritis Associated with PR3-ANCA Positive Subacute Bacterial Endocarditis

被引：20

作者：

Fukasawa, Hirotaka

Hayashi, Maho

Kinoshita, Naoko

Ishigaki, Sayaka

Isobe, Shinsuke ^{[1
]}

Sakao, Yukitoshi ^{[2
]}

Kato, Akihiko ^{[2
]}

Fujigaki, Yoshihide ^{[1
]}

Furuya, Ryuichi

机构：

[1] Hamamatsu Univ Sch Med, Dept Med 1, Hamamatsu, Shizuoka, Japan

[2] Hamamatsu Univ Sch Med, Hemodialysis Unit, Hamamatsu, Shizuoka, Japan

来源：

INTERNAL MEDICINE | 2012年 / 51卷 / 18期

关键词：

antineutrophil cytoplasmic antibody (ANCA); rapidly progressive glomerulonephritis (RPGN); subacute bacterial endocarditis (SBE); ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES; WEGENERS-GRANULOMATOSIS; INFECTIVE ENDOCARDITIS; VALVE DISEASE; ANCA; CRITERIA; PATIENT;

D O I：

10.2169/internalmedicine.51.8081

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Patients with bacterial endocarditis often have renal complications. This report presents the case of an elderly man with rapidly progressive glomerulonephritis (RPGN) associated with subacute bacterial endocarditis (SBE) due to Enterococcus faecalis infection. The patient was positive for anti-proteinase 3-antineutrophil cytoplasmic antibody (PR3-ANCA) and rheumatoid factor (RF) with hypocomplementemia. Treatment for SBE with antibiotics and the surgical replacement of the affected valves resulted in an improvement of RPGN, the disappearance of PR3-ANCA and RF, and the normalization of hypocomplementemia. This rare case suggests the importance of recognizing the cause of positive PR3-ANCA, because SBE could be an occult cause of RPGN mimicking ANCA-associated vasculitis.

引用

页码：2587 / 2590

页数：4

共 18 条

[11] Proteinase-3-antineutrophil cytoplasmic antibody (PR3-ANCA) positive crescentic glomerulonephritis in a patient with Down's syndrome and infectious endocarditis [J].