Transient receptor potential vanilloid receptor-1 confers heat resistance to male germ cells

被引：29

作者：

Mizrak, Sefika Canan ^{[1
,2
]}

van Dissel-Emiliani, Federica M. F. ^{[2
]}

机构：

[1] Acad Med Ctr, Ctr Reprod Med, Fertil Lab, NL-1105 AZ Amsterdam, Netherlands

[2] Univ Utrecht, Fac Vet Med, Dept Biochem & Cell Biol, Utrecht, Netherlands

来源：

FERTILITY AND STERILITY | 2008年 / 90卷 / 04期

关键词：

D O I：

10.1016/j.fertnstert.2007.10.081

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Testicular hyperthermia in mice lacking transient receptor potential vanilloid receptor-1 results in a much more rapid and massive germ cell depletion from the seminiferous tubules than in wild-type animals, indicating that this receptor protects germ cells against heat stress.

引用

页码：1290 / 1293

页数：4

共 27 条

[1] Extracellular cations sensitize and gate capsaicin receptor TRPV1 modulating pain signaling [J].

Ahern, GP ;

Brooks, IM ;

Miyares, RL ;

Wang, XB .

JOURNAL OF NEUROSCIENCE, 2005, 25 (21) :5109-5116

[2] Distinct thymocyte subsets express the vanilloid receptor VR1 that mediates capsaicin-induced apoptotic cell death [J].

Amantini, C ;

Mosca, M ;

Lucciarini, R ;

Perfumi, M ;

Morrone, S ;

Piccoli, M ;

Santoni, G .

CELL DEATH AND DIFFERENTIATION, 2004, 11 (12) :1342-1356

[3] Vanilloid receptor expression suggests a sensory role for urinary bladder epithelial cells [J].

Birder, LA ;

Kanai, AJ ;

de Groat, WC ;

Kiss, S ;

Nealen, ML ;

Burke, NE ;

Dineley, KE ;

Watkins, S ;

Reynolds, IJ ;

Caterina, MJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (23) :13396-13401

[4] Characterization of functional vanilloid receptors expressed by mast cells [J].

Bíró, T ;

Maurer, M ;

Modarres, S ;

Lewin, NE ;

Brodie, C ;

Acs, G ;

Acs, P ;

Paus, R ;

Blumberg, PM .

BLOOD, 1998, 91 (04) :1332-1340

[5] The vanilloid receptor: A molecular gateway to the pain pathway [J].

Caterina, MJ ;

Julius, D .

ANNUAL REVIEW OF NEUROSCIENCE, 2001, 24 :487-517

[6] Impaired nociception and pain sensation in mice lacking the capsaicin receptor [J].

Caterina, MJ ;

Leffler, A ;

Malmberg, AB ;

Martin, WJ ;

Trafton, J ;

Petersen-Zeitz, KR ;

Koltzenburg, M ;

Basbaum, AI ;

Julius, D .

SCIENCE, 2000, 288 (5464) :306-313

[7] The capsaicin receptor: a heat-activated ion channel in the pain pathway [J].

Caterina, MJ ;

Schumacher, MA ;

Tominaga, M ;

Rosen, TA ;

Levine, JD ;

Julius, D .

NATURE, 1997, 389 (6653) :816-824

[8] Biochemical pharmacology of the vanilloid receptor TRPV1 - An update [J].

Cortright, DN ;

Szallasi, A .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 2004, 271 (10) :1814-1819

[9] Immunoreactivity of VR1 on epidermal keratinocyte of human skin [J].

Denda, M ;

Fuziwara, S ;

Inoue, K ;

Denda, S ;

Akamatsu, H ;

Tomitaka, A ;

Matsunaga, K .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 285 (05) :1250-1252

[10] TRP ion channels and temperature sensation [J].

Dhaka, Ajay ;

Viswanath, Veena ;

Patapoutian, Ardem .

ANNUAL REVIEW OF NEUROSCIENCE, 2006, 29 :135-161

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