Antiplasmodial and Antibacterial Activity of Compounds Isolated from Ormocarpum trichocarpum

被引：17

作者：

Chukwujekwu, Jude C. ^{[1
]}

de Kock, Carmen A. ^{[2
]}

Smith, Peter J. ^{[2
]}

van Heerden, Fanie R. ^{[3
]}

van Staden, Johannes ^{[1
]}

机构：

[1] Univ KwaZulu Natal Pietermaritzburg, Res Ctr Plant Growth & Dev, Sch Life Sci, ZA-3209 Scottsville, South Africa

[2] Univ Cape Town, Dept Med, Div Pharmacol, ZA-7925 Cape Town, South Africa

[3] Univ KwaZulu Natal Pietermaritzburg, Sch Chem & Phys, ZA-3209 Scottsville, South Africa

来源：

PLANTA MEDICA | 2012年 / 78卷 / 17期

基金：

新加坡国家研究基金会;

关键词：

Ormocarpum trichocarpum; Papilionaceae; antiplasmodial activity; antibacterial activity; biflavanone; biscoumarin; STELLERA-CHAMAEJASME L; BIFLAVONOIDS; ASSAY; IDENTIFICATION; BIFLAVANONES; KIRKII; PLANTS;

D O I：

10.1055/s-0032-1315386

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Using activity-guided fractionation based on in vitro antibacterial assays, five biflavonoids, among them two new ones, were isolated from the aerial parts of Ormocarpum trichocarpum. The isolated compounds showed MIC values in the range of 4.0 to 136.7 mu M against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Klebsiella pneumonia and IC50 values in the range of 4.30 to 94.32 mu M against the chloroquine-sensitive D10 Plasmodium falciparum strain.

引用

页码：1857 / 1860

页数：4

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