Cytotoxic activity of gypenosides and gynogenin against non-small cell lung carcinoma A549 cells

被引：33

作者：

Chen, Dao-Jin ^{[1
]}

Liu, Hui-Min ^{[1
]}

Xing, Shao-Fang ^{[1
]}

Piao, Xiang-Lan ^{[1
]}

机构：

[1] Minzu Univ China, Inst Chinese Minor Tradit Med, Beijing 100081, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2014年 / 24卷 / 01期

关键词：

Gypenoside; Gynogenin; Non-small cell lung carcinoma (NSCLC); A549; cell; Saponins conversion; GYNOSTEMMA-PENTAPHYLLUM MAKINO; CUCURBITACEAE PLANTS; SAPONIN CONSTITUENTS; CANCER; GINSENOSIDES; APOPTOSIS;

D O I：

10.1016/j.bmcl.2013.11.043

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The activity of gypenosides and gynogenin of Gynostemma pentaphyllum against non-small cell lung carcinoma (NSCLC) A549 cells was investigated to identify the structural characteristics of gypenosides and gynogenin to have anti-NSCLC activity. Of the tested dammarane-type compounds, 20S-dammar-24-en-2a, 3b, 12b, 20-tetrol showed the strongest activity against A549 cells. Based on the structure and cytotoxic activity relationships of gypenosides and gynogenin, the OH group in C-2, the connected sugar number and the configuration in C-20 were important for cytotoxic activity against A549 cells. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：186 / 191

页数：6

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