Fabrication and Reduction of pH Dual Bio-Responsive Poly(ether-urethane) Nanocarriers for Targeted Drug Delivery

被引：8
|
作者：
Li, Liubing [1 ]
Lu, Yufeng [1 ]
Zhang, Moyu [2 ,3 ]
Zhao, Yuhao [2 ,3 ]
Li, Xueqing [2 ,3 ]
Dong, Qirong [1 ]
Shen, Liqin [1 ]
Wang, Yangyun [2 ,3 ]
机构：
[1] Soochow Univ, Affiliated Hosp 2, Suzhou 215004, Peoples R China
[2] Soochow Univ, Collaborat Innovat Ctr Radiat Med, Jiangsu Higher Educ Inst, Sch Radiol & Interdisciplinary Sci RAD X, Suzhou 215123, Peoples R China
[3] Soochow Univ, Sch Radiat Med & Protect, Suzhou 215123, Peoples R China
来源：
NANOSCIENCE AND NANOTECHNOLOGY LETTERS | 2018年 / 10卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Poly(ether-urethane); Dual-Responsive Nanocarriers; Targeted and Efficient Drug Delivery; ELECTROCATALYTIC ACTIVITY; COMPOSITE ELECTRODE; BLOCK-COPOLYMERS; ANTICANCER DRUG; GRAPHENE OXIDE; NANOPARTICLES; REDOX; DOXORUBICIN; CONJUGATE; MICELLES;
D O I：
10.1166/nnl.2018.2588
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
This current study employed pH-and GSH-sensitive copolymers to prepare nanocarriers for targeted and efficient drug delivery. The nanocarriers were constructed by a family of dual pH-and GSH-responsive copolymers synthesized from poly(ethylene glycol) (PEG), 2,2'-dithiodiethanol (DiT), N-methyldiethanolamine (MDEA) and hexamethylene diisocyanate (HDI). As a commonly used targeting ligand, hyaluronic acid (HA) chains were found to be semi-interpenetrated into the surface of the nanocarriers. Results from these studies demonstrated that the DOX-loaded dual stimuli-responsive nanocarriers with HA modification exhibited excellent tumor targeting, successful cell intake, and anti-cancer activity with minimal systemic toxicity. The DOX-loaded dual stimuli-responsive nanocarriers have special potential for targeted therapy against CD44-expressing tumor.
引用
收藏
页码：13 / 22
页数：10
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