Fabrication and Reduction of pH Dual Bio-Responsive Poly(ether-urethane) Nanocarriers for Targeted Drug Delivery

被引：8

作者：

Li, Liubing ^{[1
]}

Lu, Yufeng ^{[1
]}

Zhang, Moyu ^{[2
,3
]}

Zhao, Yuhao ^{[2
,3
]}

Li, Xueqing ^{[2
,3
]}

Dong, Qirong ^{[1
]}

Shen, Liqin ^{[1
]}

Wang, Yangyun ^{[2
,3
]}

机构：

[1] Soochow Univ, Affiliated Hosp 2, Suzhou 215004, Peoples R China

[2] Soochow Univ, Collaborat Innovat Ctr Radiat Med, Jiangsu Higher Educ Inst, Sch Radiol & Interdisciplinary Sci RAD X, Suzhou 215123, Peoples R China

[3] Soochow Univ, Sch Radiat Med & Protect, Suzhou 215123, Peoples R China

来源：

NANOSCIENCE AND NANOTECHNOLOGY LETTERS | 2018年 / 10卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Poly(ether-urethane); Dual-Responsive Nanocarriers; Targeted and Efficient Drug Delivery; ELECTROCATALYTIC ACTIVITY; COMPOSITE ELECTRODE; BLOCK-COPOLYMERS; ANTICANCER DRUG; GRAPHENE OXIDE; NANOPARTICLES; REDOX; DOXORUBICIN; CONJUGATE; MICELLES;

D O I：

10.1166/nnl.2018.2588

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

This current study employed pH-and GSH-sensitive copolymers to prepare nanocarriers for targeted and efficient drug delivery. The nanocarriers were constructed by a family of dual pH-and GSH-responsive copolymers synthesized from poly(ethylene glycol) (PEG), 2,2'-dithiodiethanol (DiT), N-methyldiethanolamine (MDEA) and hexamethylene diisocyanate (HDI). As a commonly used targeting ligand, hyaluronic acid (HA) chains were found to be semi-interpenetrated into the surface of the nanocarriers. Results from these studies demonstrated that the DOX-loaded dual stimuli-responsive nanocarriers with HA modification exhibited excellent tumor targeting, successful cell intake, and anti-cancer activity with minimal systemic toxicity. The DOX-loaded dual stimuli-responsive nanocarriers have special potential for targeted therapy against CD44-expressing tumor.

引用

页码：13 / 22

页数：10

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